双孔通道结构及激活机制的研究进展

Research progress of structure and activation mechanism of TPCs

双孔通道(two-pore channels,TPCs)是一类位于内溶酶体膜上的非选择性阳离子渗透性通道,也是电压门控离子通道(voltage-gated ion channel,VGICs)超家族中进化上的重要成员。双孔通道广泛存在于动植物中,主要以酸性储存的方式表达。该文综述了TPCs的结构、分布以及TPCs激活机制研究进展,并将目前有关TPCs与相关配体激活研究过程中存在的问题加以总结,旨在为今后研究和治疗以TPCs为靶向的相关疾病提供参考。

Two-pore channels(TPCs) are a kind of non-selective cation permeable channels located on endolysosomal membranes,and they are also an important evolutionary member of the voltage-gated ion channels(VGICs) superfamily.TPCs are widespread across animals and plants.They are mainly expressed in acidic stores.This paper reviews the research progress about the structure,distribution and activation mechanism of TPCs,and the current problem in the research on how TPCs are activated by their ligands were summarized,aiming to provide reference for the future research and treatment of related diseases targeted TPCs.