结肠癌切除术前外周血NLR、PLR、MPV、PCT、ESR水平变化及临床意义

Changes of NLR,PLR,MPV,PCT and ESR in peripheral blood before colon cancer resection and their clinical significance

目的 探讨结肠癌切除术前外周血中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比率(PLR)、血小板平均体积(MPV)、降钙素原(PCT)、红细胞沉降率(ESR)水平变化及临床意义。方法 回顾性分析浙江省海宁市中心医院2017年6月至2022年6月进行结肠癌切除术56例患者的病历作为观察组,并选择同期在本院体检的56位身体健康人群作为对照组。比较两组NLR、PLR、MPV、PCT、ESR水平,比较不同TNM分期结肠癌患者NLR、PLR、MPV、PCT、ESR水平,并采用Pearson相关分析法分析NLR、PLR、MPV、PCT、ESR水平与TNM分期的相关性。结果 观察组患者的NLR、PLR、MPV、PCT、ESR水平分别为(5.68±0.20)、(162.49±25.01)、(13.18±1.26)fL、(2.40±0.47)μg/L、(15.11±2.30) mm/h,均明显高于对照组的(1.62±0.24)、(84.15±12.30)、(5.87±0.75)fL、(0.81±0.15)μg/L、(9.30±1.74) mm/h,差异有统计学意义(P<0.05);Ⅲ期结肠癌患者NLR、PLR、MPV、PCT、ESR水平分别为(7.13±0.80)、(185.15±26.55)、(14.45±1.65) fL、(3.55±0.47)μg/L、(15.11±2.30) mm/h,明显高于Ⅰ+Ⅱ期结肠癌患者的(6.12±0.64)、(167.22±18.01)、(12.03±0.89) fL、(2.02±0.25)μg/L、(9.30±1.74) mm/h,差异有统计学意义(P<0.05);经Pearson相关分析结果显示,NLR、PLR、MPV、PCT、ESR水平与TNM分期均呈正相关(r值=0.704、0.620、0.574、0.856、0.712,P<0.05)。结论 外周血NLR、PLR、MPV、PCT、ESR水平在结肠癌患者切除术前有明显高表达,且与TNM肿瘤的发展程度密切相关。

Objective To investigate the changes of neutrophil-lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),mean platelet volume(MPV),procalcitonin(PCT) and erythrocyte sedimentation rate(ESR) in peripheral blood before colon cancer resection and their clinical significance.Methods The medical records of 56 patients who underwent colon cancer resection in our hospital from June 2017 to June 2022 were retrospectively analyzed as the observation group,and 56 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.The levels of NLR,PLR,MPV,PCT and ESR were compared between the two groups.The levels of NLR,PLR,MPV,PCT and ESR in colon cancer patients with different TNM stages were compared,and the correlation between the levels of NLR,PLR,MPV,PCT and ESR and TNM stages was analyzed by Pearson correlation analysis.Results The levels of NLR,PLR,MPV,PCT and ESR in observation group were(5.68 ±0.20),(162.49 ±25.01),(13.18 ±1.26) fL,(2.40 ±0.47) μg/L and(15.11 ±2.30) mm/h,significantly higher than the control group(1.62 ±0.24),(84.15 ±12.30),(5.87±0.75) fL,(0.81±0.15) μg/L,(9.30±1.74) mm/h,the difference were statistically significant(P0.05).The levels of NLR,PLR,MPV,PCT and ESR in Stage Ⅲ colon cancer patients were(7.13 ±0.80),(185.15 ±26.55),(14.45 ±1.65) fL,(3.55 ±0.47) μg/L and(15.11 ±2.30) mm/h,significantly higher than(6.12±0.64),(167.22±18.01),(12.03±0.89) fL,(2.02±0.25) μg/L,(9.30±1.74) mm/h in stage Ⅰ+Ⅱ colon cancer patients,the difference were statistically significant(P<0.05).Pearson correlation analysis showed that the levels of NLR,PLR,MPV,PCT and ESR were positively correlated with TNM staging(r value=0.704,0.620,0.574,0.856,0.712,P<0.05).Conclusion The levels of NLR,PLR,MPV,PCT and ESR in peripheral blood were significantly high in patients with colon cancer before resection,and were closely related to the development of TNM tumors.