急性胰腺炎并发胰腺假性囊肿危险因素的meta分析

Meta-analysis of risk factors for pancreatic pseudocyst in acute pancreatitis

目的运用meta分析系统评价急性胰腺炎并发胰腺假性囊肿的危险因素,为预防胰腺假性囊肿形成及治疗提供循证医学依据。方法检索Medline数据库、Embase、Cochrane Library、web of science、中国知网、CBM、万方数据库、维普数据库自建库至2022年11月收录的所有相关文献,按纳入和排除标准筛选文献,用纽卡斯尔-渥太华量表(NOS)进行质量评价,Review Manager 5.4、Stata 14软件进行meta分析,用漏斗图评价发表偏倚。结果共纳入14篇文献,meta分析结果示:男性OR=3.94,95%CI(2.12,7.31),P<0.01;糖尿病病史OR=2.62,95%CI(2.04,3.36),P<0.01;CT严重指数(CTSI)OR=1.50,95%CI(1.31,1.72),P<0.01;血清白蛋白水平OR=0.88,95%CI(0.83,0.92),P<0.01;既往饮酒史OR=4.36,95%CI(2.77,6.88),P<0.01;既往胰腺炎病史OR=2.73,95%CI(1.15,6.51),P<0.01。结论本研究显示男性、糖尿病病史、CTSI、血清白蛋白水平、既往饮酒史、既往胰腺炎病史与急性胰腺炎并发胰腺胰假性囊肿有关。

Objective To evaluate the risk factors of pancreatic pseudocysts in acute pancreatitis using a meta-analysis system,providing evidence based medical evidence for the prevention and treatment of pancreatic pseudocyst.Methods All relevant literature included in Medline database,Embase,Cochrane Library,web of science,CNKI,CBM,Wanfang database and VIP database from the establishment to November 2022 were first searched.The literature were then screened according to the inclusion and exclusion criteria.The Newcastle-Ottawa Scale(NOS)was used for quality evaluation.Review Manager 5.4 and Stata 14 software were applied for meta-analysis.Publication bias was evaluated by Funnel plot.Results A total of 14 articles were finally included.Meta-analysis results showed that male OR=3.94,95%CI=(2.12-7.31),P<0.01;diabetes history OR=2.62,95%CI=(2.04-3.36),P<0.01;CT severity index(CTSI)OR=1.5,95%CI=(1.31-1.72),P<0.01;serum albumin level OR=0.88,95%CI=(0.83-0.92),P<0.01;previous drinking history OR=4.36,95%CI=(2.77-6.88),P<0.01;previous history of pancreatitis OR=2.73,95%CI=(1.15-6.51),P<0.01;the differences were statistically significant.Conclusion Male,diabetes history,CTSI,serum albumin level,previous drinking history,and previous history of pancreatitis were associated with acute pancreatitis complicated with pancreatic pseudocyst.