血塞通注射液辅助治疗急性脑梗死的效果观察

Effect observation of Xuesaitong injection in the adjuvant treatment of acute cerebral infarction

目的 探讨血塞通注射液辅助治疗急性脑梗死的效果,以期为临床治疗提供参考。方法 选取河南省许昌市立医院2018年6月—2020年6月收治的78例急性脑梗死患者作为研究对象。采用随机数字表法将患者分为对照组与研究组,每组39例。对照组患者在常规溶栓治疗基础上,采用丁苯酞治疗;研究组患者在对照组治疗基础上采用血塞通注射液治疗。比较2组患者治疗前后的低切、中切、高切全血黏度,D-二聚体、血清超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,以及美国国立卫生研究院卒中量表(NIHSS)和日常生活能力(ADL)评分。结果 治疗前,2组患者低切全血黏度、中切全血黏度、高切全血黏度及D-二聚体水平比较,差异无统计学意义(P>0.05)。治疗后,2组患者低切全血黏度、中切全血黏度、高切全血黏度及D-二聚体水平均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者hs-CRP、IL-6、TNF-α水平比较,差异无统计学意义(P>0.05)。治疗后,2组患者hs-CRP、IL-6、TNF-α水平均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者NIHSS及ADL评分比较,差异无统计学意义(P>0.05)。治疗后,2组患者NIHSS评分低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05);2组患者ADL评分高于治疗前,且研究组高于对照组,差异均有统计学意义(P<0.05)。结论 采用血塞通注射液辅助治疗急性脑梗死,可有效改善患者血液高凝状态、减轻炎症反应,降低神经功能缺损程度,提高患者自主生活能力,值得临床推广应用。

Objective This study attempted to investigate the effect of Xuesaitong injection in the adjuvant treatment of acute cerebral infarction to provide evidence for clinical treatment.Methods A total of 78 patients with acute cerebral infarction admitted to Xuchang Municipal Hospital from June 2018 to June 2020 were selected as the study participants.They were randomly assigned to a control group and a study group,with 39 cases in each group.The control group received treatment with dipyridamole based on routine thrombolytic therapy,while the study group received Xuesaitong injection in addition to the treatment received by the control group.The low shear blood viscosity,medium shear blood viscosity,high shear blood viscosity,D-dimer,high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)levels,and the National Institutes of Health Stroke Scale(NIHSS)and Activities of Daily Living(ADL)scale of the two groups were compared before and after treatment.Results Before treatment,there was no statistically significant difference in the low shear blood viscosity,medium shear blood viscosity,high shear blood viscosity,and D-dimer levels between the two groups(P>0.05).After treatment,the low shear blood viscosity,medium shear blood viscosity,high shear blood viscosity,and D-dimer levels in both groups were decreased,and the study group was significantly lower than the control group(P<0.05).Before treatment,there was no significant difference in hs-CRP,IL-6,and TNF-αlevels between the two groups(P>0.05).After treatment,the hs-CRP,IL-6,and TNF-αlevels in both groups were lower than those before treatment,and the study group was significantly lower than the control group(P<0.05).Before treatment,there was no statistically significant difference in NIHSS and ADL scores between the two groups(P>0.05).After treatment,the NIHSS scores in both groups showed a decrease,and the study group was significantly lower than the control group(P<0.05);The ADL scores of both groups were showed an increase,and the study group was significantly higher than the control group(P<0.05).Conclusion The use of Xuesaitong injection in the adjuvant treatment of acute cerebral infarction can further improve the patients'blood hypercoagulable state effectively,reduce the inflammatory response,lower the degree of neurological dysfunction,and improve the patients'ability to live independently.These benefits hold promise for a wider application of this procedure clinically.