综合护理干预在初发急性早幼粒细胞白血病合并颅内出血患者中的应用

Application of comprehensive nursing intervention in patients with primary acute promyelocytic leukemia comorbid with intracranial hemorrhage

目的 探讨初发急性早幼粒细胞白血病合并颅内出血患者采用综合护理干预的效果。方法 选取2020年1月—2022年4月南阳医学高等专科学校第一附属医院收治的80例初发急性早幼粒细胞白血病合并颅内出血患者为研究对象,所有患者均经系统治疗及对症处理,并配合综合护理干预。干预4周后评估临床疗效,凝血功能指标、不良情绪指标的变化情况以及护理满意度。结果 本组患者治疗4周后完全缓解率为77.50%(62/80),部分缓解率为17.50%(14/80),未缓解率为5.00%(4/80)。本组患者干预后D-二聚体(D-D)水平低于干预前,凝血酶原时间(PT)及活化部分凝血活酶时间(APTT)长于干预前,差异均有统计学意义(P<0.05)。本组患者干预后焦虑自评量表(SAS)评分及抑郁自评量表(SDS)评分均低于干预前,差异均有统计学意义(P<0.05)。本组患者护理满意度为96.25%(77/80)。结论 初发急性早幼粒细胞白血病合并颅内出血患者在临床治疗的同时给予综合护理干预,有助于提高临床治疗效果,降低死亡风险,还可改善患者凝血功能,缓解患者不良情绪。

Objective This study aimed to investigate the effect of comprehensive nursing intervention in patients with primary acute promyelocytic leukemia comorbid with intracranial hemorrhage.Methods This study included 80 patients with primary acute promyelocytic leukemia with intracranial hemorrhage admitted to the First Affiliated Hospital of Nanyang Medical College from January 2020 to April 2022 as the study participants.All patients received systematic and symptomatic treatment,combined with comprehensive nursing intervention.After 4 weeks of intervention,clinical efficacy,changes in coagulation parameters,adverse mood parameters,and nursing satisfaction were assessed.Results After 4 weeks of treatment,the complete remission rate was 77.50%(62/80),the partial remission rate was 17.50%(14/80),and the non-remission rate was 5.00%(4/80).In this group,the D-dimer(D-D)level after intervention was lower than that before intervention,prothrombin time(PT)and activated partial thromboplastin time(APTT)were significantly longer than those before intervention(P<0.05).The self-rating anxiety scale(SAS)and Self-rating depression scale(SDS)scores of patients in the group after intervention were significantly lower than those before intervention(P<0.05).The satisfaction rate of nursing in this group was 96.25%(77/80).Conclusion Together with clinical treatment,comprehensive nursing intervention in patients with primary acute promyelocytic leukemia comorbid with intracranial hemorrhage is conducive to improving the clinical treatment outcomes,reducing the risk of death,enhancing the coagulation function,and alleviating their adverse emotions.