基于中医传承计算平台分析蔡淦教授的膏方用药规律

Analysis of Professor Cai Gan’s plaster drug law based on traditional Chinese medicine inheritance computing platform

目的采用中医传承计算平台挖掘蔡淦教授膏方的用药规律及特色。方法收集2017年11月至2021年12月上海中医药大学附属曙光医院脾胃病科蔡淦教授膏方门诊处方,采用中医传承计算平台V 3.0挖掘蔡淦教授膏方组方规律和辨治经验。结果总计整理并分析1316张膏方,共使用369种药物,其中高频药物共12味(频数≥1000次),用药以温性药物最多,其次为平性和寒性,药味以甘、苦、辛为主,归经以脾、胃、肝、肾最多,药物功效以补虚药为主,配伍清热、理气、活血等。根据关联规则网络拓扑分析获得3组核心膏方组合,K-Means聚类得到5组针对兼证的特色药物组合。结论蔡教授的膏方特点:辨治主张治脾胃以安五脏,用药注重寒温适宜,性质平和,升降同调,动静结合,疏补兼顾。

Objective To explore the application rules and characteristics of Professor Cai Gan’s ointment using traditional Chinese medicine inheritance computing platform.Methods Outpatient prescriptions of paste prescription of Professor Cai Gan from the Department of Spleen and Stomach Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from November 2017 to December 2021 were collected.The traditional Chinese medicine inheritance computing platform V 3.0 was adopted to explore the rules of the tutor’s paste prescription,and the discrimination and treatment experience.Results A total of 1316 plaster prescriptions were sorted out and analyzed.A total of 369 kinds of drugs were used,including 12 kinds of high-frequency drugs(frequency≥1000 times).The drugs of warm nature were the most commonly used drugs,followed by drugs of flat and cold nature;the drugs mainly tasted sweet,bitter,and pungent;and most drugs entered the spleen,stomach,liver,and kidney meridian;the efficacy of drugs were mainly tonify deficiency,with clearing heat,regulating qi,promoting blood,etc.According to the network topology analysis of association rules,three groups of core plaster prescriptions combinations were obtained,and five groups of characteristic drug combinations targeting accompanied syndromes were obtained by K-Means clustering.Conclusion The characteristics of professor Cai Gan’s ointment prescription are as follows:distinguishing and treating the spleen and stomach to soothe the five viscera,paying attention to the appropriate use of cold and temperature,being peaceful in nature,harmonizing the rise and fall,combining static and dynamic,and giving consideration to the drainage and complement.