基于数据挖掘探讨杜雨茂教授治疗慢性肾衰竭的组方用药规律

Study on medication rules of Professor Du Yumao in the treatment of chronic renal failure based on data mining

目的运用数据挖掘技术探讨杜雨茂教授治疗慢性肾衰竭的组方用药规律。方法以咸阳雨茂医院病案为资料来源,收集并整理杜教授于1998年1月至2011年12月所治疗的慢性肾衰竭患者病案,应用中医传承辅助平台(V2.5),统计分析用药频次、性味归经,利用关联规则和聚类算法得出常用药物组合及潜在新方。结果共纳入符合研究标准的处方640首,涉及中药214味,用药频次≥40的有59味,发现杜教授治疗慢性肾衰竭主要由补虚药、利水渗湿药、活血化瘀药等组成。其中,补气首选白术,补阳常用淫羊藿,滋阴多用天冬;用药药性以寒、温为主,药味以甘、苦、辛为多,主要归入肝、脾经。通过关联规则分析得到核心药物8味,具体为白术、黄芪、茯苓、丹参、柴胡、炒黄芩、川芎、虎杖;得到2味药关联规则14条,3味药关联规则25条;聚类分析得到潜在新方4个。结论本研究分析杜教授治疗慢性肾衰竭的组方用药规律,发现潜在新方,对临床治疗有指导意义。

Objective To explore medication rules of Professor Du Yumao in the treatment of chronic renal failure based on data mining technology.Methods The medical records of chronic kidney failure patients treated by Professor Du from January 1998 to December 2011 were collected and organized based on the medical records of Xianyang Yumao Hospital.The traditional Chinese medicine inheritance assistance platform(V2.5)was applied to statistical analysis of medication frequency,sexual taste and meridian distribution.Association rules and clustering algorithms were used to derive commonly used drug combinations and potential new prescriptions.Results A total of 640 prescriptions that met the research criteria were included,involving 214 traditional Chinese medicines.Among them,59 flavors with medication frequency more than 40 times.It was found that Professor Du in the treatment of chronic renal failure mainly consists of tonifying deficiency drugs,diuretic and dampness absorbing drugs,and blood activating and stasis resolving drugs.Among them,Atractylodis Macrocephalae Rhizoma was the preferred method for tonifying qi,Epimedii Folium was commonly used for tonifying yang,and Asparagi Radix was commonly used for nourishing yin.The medicinal properties of the medicine were mainly cold and warm,and the medicinal flavors were mainly sweet,bitter,and spicy,mainly classified into the liver and spleen meridians.Through association rule analysis,eight core drugs were obtained,including Atractylodis Macrocephalae Rhizoma,Astr-agali Radix,Poria,Salviae Miltiorrhizae Radix Et Rhizoma,Bupleuri Radix,Scutellariae Radix,Chuanxiong Rhizoma,and Polygoni Cuspidati Rhizoma Et Radix.Fourteen association rules for two drugs were obtained,and 25 association rules for three drugs were obtained.Four potential new parties were identified through cluster analysis.Conclusion This study analyzes the medication rules of Professor Du in the treatment of chronic kidney failure and identifies potential new prescriptions,which have guiding significance for clinical treatment.