摘要
心血管疾病是世界公共卫生问题,是人类主要的死亡原因之一。治疗性血管新生能够有效减轻心肌缺血损伤并改善心功能,已成为心肌缺血后重要的补充治疗策略。周细胞-内皮细胞Crosstalk对心肌缺血后微血管新生的调控机制主要包括周细胞通过血管基底膜直接接触内皮细胞和旁分泌调节两种模式。其中,旁分泌调节主要通过促血管新生细胞因子和激活多种信号通路,以促进微血管新生和成熟,对稳定血管/血液系统及改善心脏功能等具有重要作用,因此,周细胞-内皮细胞Crosstalk是心肌缺血后微血管新生的关键环节。本文综述了周细胞-内皮细胞Crosstalk在心肌缺血后微血管新生中的机制及作用,以期为心肌缺血的补充治疗方案提供思路。
Cardiovascular disease is a world public health problem and one of the main causes of human death.Therapeutic angiogenesis can effectively alleviate myocardial ischemia injury and improve cardiac function,which has become an important supplementary treatment strategy after myocardial ischemia.The regulation mechanism of pericyte-endothelial cell Crosstalk on micro angiogenesis after myocardial ischemia mainly includes pericyte contact with endothelial cells through vascular basement membrane and paracrine regulation.Paracrine regulation plays an important role in stabilizing blood vessel/blood system,and improving cardiac function by promoting angiogenesis cytokines,and activating various signal pathways to promote angiogenesis and maturation.Therefore,pericyte-endothelial cell Crosstalk is the key link of micro angiogenesis after myocardial ischemia.This paper reviews the mechanism and role of pericyte-endothelial cell Crosstalk in micro angiogenesis after myocardial ischemia in order to provide ideas for complementary treatment of myocardial ischemia.
作者
刘艺旋
汤凯璇
李奕潼
周煊程
刘怡然
李超
LIU Yixuan;TANG Kaixuan;LI Yitong;ZHOU Xuancheng;LIU Yiran;LI Chao(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan250355,China;College of Medicine,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250355,China;Institute of innovation in Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan250355,China)
出处
《中国医药导报》
CAS
2023年第15期40-44,共5页
China Medical Herald
基金
国家自然科学基金资助项目(82004276)
省级大学生创新训练计划项目(S202210441019)。
