肺康复训练联合个体化营养干预对非小细胞肺癌患者术后康复的影响

Effect of lung rehabilitation training combined with individualized nutrition intervention on postoperative rehabilitation of patients with non-small cell lung cancer

目的探讨肺康复训练联合个体化营养支持对肺癌患者术后康复的影响,为肺癌患者术后加速康复方法提供临床实践依据。方法选取2021年5月至2022年6月该院收治的拟行肺癌手术的非小细胞肺癌患者,采用随机数字表法分为试验组(n=78)与对照组(n=76)。试验组在术前2周开始进行肺康复训练,同时为患者制订个体化营养方案;对照组不进行肺康复训练,不给予个体化营养干预。比较两组患者生活质量、肺功能指标、6 min步行距离(6MWD)、营养状况指标及术后并发症发生情况。结果术后12周,试验组肺癌特异性生活质量评估表(FACT-L)各维度评分均高于对照组,差异有统计学意义(P<0.05);术后4、8、12周,试验组肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)占预计值的百分比(FEV_(1)%pred)等]、6MWD、营养状况指标[体重指数、血清总蛋白、清蛋白及血红蛋白水平]均高于对照组,差异有统计学意义(P<0.05)。试验组术后肺部并发症总发生率明显低于对照组(9.0%vs.46.0%,P<0.05)。结论肺康复联合营养干预可促进肺癌患者术后康复。

Objective To explore the effect of lung rehabilitation training combined with individualized nutritional support on postoperative rehabilitation of lung cancer patients,and to provide clinical practice basis for accelerating postoperative rehabilitation of lung cancer patients.Methods The patients with non-small cell lung cancer who were admitted to this hospital for lung cancer operation from May 2021 to June 2022 were selected and divided into the experimental group(n=78)and the control group(n=76)according to the random number table.The experimental group received lung rehabilitation training two weeks before operation,and at the same time individual nutrition program was established for the patients.The control group did not receive lung rehabilitation training and individualized nutritional intervention.The quality of life,lung function,6-minutes walking distance(6MWD),nutritional status and postoperative complications between the two groups were compared.Results The scores of each dimension of the functional assessment of cancer treatment-lung(FACT-L)in the experimental group 12 weeks after operation were higher than those in the control group,and the differences were statistically significant(P<0.05).At 4,8 and 12 weeks after operation,the lung function indicators,including the forced expiratory volume in one second(FEV_(1)),the forced vital capacity(FVC)and FEV_(1)/predicted value ratio(FEV_(1)%pred),6MWD,and nutritional status indexes,including body mass index,serum total protein,albumin and hemoglobin in the experimental group were significantly higher than those in the control group(P<0.05).The total incidence of postoperative pulmonary complications in the experimental group was significantly lower than that in the control group(9.0%vs.46.0%,P<0.05).Conclusion Lung rehabilitation combined with nutritional intervention can promote postoperative rehabilitation of lung cancer patients.