生存素和自然杀伤T细胞在宫颈癌中的表达及价值

Expression and value of Survivin and NKTs in cervical cancer

目的探讨宫颈癌患者癌组织中生存素(Survivin)表达及自然杀伤T细胞(NKTs)水平及其临床意义。方法以2021年1月至2022年3月保定市第二中心医院接诊的152例宫颈癌患者为宫颈癌组,另选同期接受体检的健康受试者80例为健康组,对比两组NKTs、Survivin、癌胚抗原(CEA)、糖类抗原125(CA125)、血管内皮生长因子(VEGF)、白细胞介素-12(IL-12)表达水平;采用ROC曲线分析血清各指标诊断宫颈癌的效能。结果宫颈癌组血清NKTs、CEA、CA125、VEGF水平均高于健康组,IL-12水平低于健康组(P<0.01)。Ⅲ~Ⅳ期宫颈癌癌组织中Survivin及血清CEA、CA125、VEGF水平高于Ⅰ~Ⅱ期组,NKTs、IL-12低于Ⅰ~Ⅱ期组(P<0.01)。血清指标联合检测诊断宫颈癌的效能最高(AUC=0.996,敏感度为92.00%,特异度为96.00%)。宫颈癌患者NKTs与Survivin表达呈负相关(r=-0.657,P<0.01)。结论宫颈癌患者临床病理分期越高,癌组织中Survivin表达越高,NKTs水平越低,宫颈癌可采用血清NKTs、CEA、CA125、VEGF、IL-12联合检测。

Objective To investigate the expression of Survivin and level of natural killer T cells(NKTs)in patients with cervical cancer and its clinical significance.Methods A total of 152 cervical cancer patients admitted to the NO.2 Hospital of Baoding from January 2021 to March 2022 were selected as cervical cancer group,and 80 healthy subjects received physical examination during the same period were selected as healthy group.The expression levels of NKTs,Survivin,carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),vascular endothelial growth factor(VEGF),and interleukin-12(IL-12)were compared between two groups.The ROC curve was used to analyze the efficacy of various serum indicators in the diagnosis of cervical cancer.Results Compared with healthy group,serum levels of NKTs,CEA,CA125 and VEGF were significantly increased,while IL-12 was significantly decreased in cervical cancer group(P<0.01).Compared with stageⅠ-Ⅱcervical cancer,the levels of Survivin and serum CEA,CA125,VEGF were higher,while the levels of NKTs,IL-12 were lower in stageⅢ-Ⅳ(P<0.01).The combined of serum indicators had the highest efficiency in the diagnosis of cervical cancer(AUC=0.996,sensitivity=92.00%,specificity=96.00%).There was a negative correlation between NKTs and Survivin expression in cervical cancer patients(r=-0.657,P<0.01).Conclusion The higher the clinicopathological stage of cervical cancer patients,the higher the expression of Survivin in the cancer tissue,and the lower the serum NKTs level.Cervical cancer can be jointly detected with serum NKTs,CEA,CA125,VEGF,and IL-12.