基于数据挖掘探究白彦萍教授治疗白癜风的用药规律

Exploration the medication rules of Professor Bai Yanping in treatment of vitiligo based on data mining

目的基于数据挖掘技术分析白彦萍教授治疗白癜风的用药规律。方法收集2010年4月至2020年9月中日友好医院白彦萍教授治疗白癜风的中药方剂,描述性分析中药的频次、分类、功效、四气、五味及归经,通过关联规则和聚类分析挖掘潜在药物组合,通过网络图实现数据可视化。结果纳入研究的方剂535个,中药221味,在药性方面,以温性药为主,寒、平性药次之;在药味方面,以苦味药最多,甘、辛药味次之;在药物归经方面,入肝经药物出现频次最高。在中药分类上,则以补虚药应用最多。治疗最常用的药物为补骨脂。关联规则法分析得到41个白癜风常用药物组合;聚类分析得到2个潜在新处方。结论研究得出的用药规律与白彦萍教授治疗白癜风以虚论治,攻补兼施为基础,兼以养血疏风,通窍袪白,调和阴阳的理论相符,效果显著。

Objective To analyze the medication rules of Professor Bai Yanping in the treatment of vitiligo based on data mining technology.Methods The Chinese medicine prescriptions for vitiligo treated by Professor Bai Yanping in China-Japan Friendship Hospital from April 2010 to September 2020 were collected.The frequency,classification,efficacy,four nature,five flavours,and channel tropism of Chinese medicine were analyzed descriptively.The potential drug combinations were explored through association rules and cluster analysis,and data visualization was realized through network diagram.Results A total of 535 prescriptions and 221 Chinese medicines were included in the study.In terms of drug natures,warm drugs were the main drugs,followed by cold and plain drugs.In the aspect of drug flavours,bitter drugs were the most,followed by sweet and pungent drugs.In the aspect of drug channel tropism,the frequency of drugs entering liver channel was the highest.In the classification of Chinese medicine,tonifying deficiency medicine was the most used.The most commonly used drug for treatment was Psoraleae Fructus.Forty-one drug combinations of vitiligo were obtained by association rule analysis.Two potential new prescriptions were obtained by cluster analysis.Conclusion The medication rules obtained in this study is consistent with professor Bai Yanping’s theory of treating vitiligo based on treating from etiology of deficiency,treatment with both attack and supplementation,nourishing blood and dispelling wind,ridding the body of white,and harmonizing yin and yang,the efficacy of which is remarkable.