富血小板纤维蛋白治疗慢性创面的临床应用研究

The research on clinical use of platelet-rich fibrin in treatment of chronic wounds

目的观察富血小板纤维蛋白(platelet rich fibrin,PRF)治疗慢性创面的临床效果,为PRF治疗慢性创面的应用提供依据。方法2014年1月~2022年1月我院接受治疗的慢性创面病人86例,将其随机分配至常规治疗组和PRF治疗组,每组各43例。观察两组治疗前后感染控制情况、创面面积变化、视觉模拟评分、压疮愈合评分、生活质量评分情况及治疗费用与时间,对比PRF治疗效果。结果治疗前观察组与对照组肿瘤坏死因子(TNF)-α水平、白细胞介素(IL)-2和IL-8水平、肉芽组织评分、创面面积、视觉模拟评分、压疮愈合评分、负面情绪评分、生活质量评分比较差异无统计意义(P>0.05);两组治疗后与治疗前比较差异有统计学意义(P<0.05);两组治疗后比较差异有显著统计学意义(P<0.05)。两组治疗费用及时间比较差异有统计学意义(P<0.05)。两组治疗效果比较差异有统计学意义(P<0.05)。结论将PRF应用于慢性创面治疗,可减轻病人体内炎性因子水平,控制感染程度,减小创面面积,缓解疼痛程度,提高生活质量,同时可有效减少治疗费用和创面愈合时间。

Objective To observe more cases and indexs of platelet rich fibrin(PRF)application on chronic wounds,which provide solid basis for the application of PRF on the treatment of chronic wounds.Methods 86 patients with chronic wounds treated in our hospital from January 2014 to January 2022 were selected.The odd and even number grouping was used to guide the patients to draw numbers by themselves.The patients with odd numbers were classified as the control group(routine treatment),and the patients with even numbers were classified as the observation group(PRF treatment).The number of patients in each group was 43.The infection control,wound area change,VAS score,push score,quality of life score,cost and time after treatment were observed before and after treatment,and the therapeutic effect of PRF was summarized.Results Before treatment in the observation group and the control group TNF-αLevel,IL-2,IL-8,granulation tissue score,wound area,VAS score,push score,negative emotion score and quality of life score were not statistically significant(P>0.05).There was significant difference between the two groups after treatment and before treatment(P<0.05).There was significant statistical significance between the two groups after treatment(P<0.05).There was significant difference in treatment cost and time between the two groups(P<0.05).The therapeutic effect of the two groups was statistically significant(P<0.05).Conclusion The application of PRF on the treatment of chronic wounds can effectively reduce the level of inflammatory factors in patients,control the degree of infection,reduce the wound area,alleviate the pain degree of patients and improve the quality of life.At the same time,it can effectively reduce the treatment cost and wound healing time.