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香菇多糖联合SOX方案治疗晚期结肠癌临床研究

Clinical Study on Lentinan Combined with SOX Scheme for Advanced Colorectal Carcinoma
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摘要 目的:观察香菇多糖联合替吉奥^(+)奥沙利铂(SOX)方案治疗晚期结肠癌的临床疗效及对免疫功能的影响。方法:将58例晚期结肠癌患者按随机数字表法分为对照组、观察组各29例。对照组给予SOX方案治疗,观察组在对照组基础上加用香菇多糖治疗。比较2组治疗前后中医证候评分、免疫球蛋白及T淋巴细胞亚群水平,并评估2组临床疗效及不良反应发生情况。结果:治疗后,对照组总有效率68.97%,观察组总有效率82.76%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组胃脘痛满、食少纳呆、体倦乏力、大便硬溏、舌淡苔薄中医证候评分均较治疗前降低(P<0.05),且观察组中医证候评分低于对照组(P<0.05)。治疗后,对照组免疫球蛋白(Ig)A、IgM、IgG、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较治疗前降低(P<0.05),CD8^(+)升高(P<0.05);观察组IgA、IgM、IgG、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较治疗前升高(P<0.05),CD8^(+)降低(P<0.05);观察组治疗后IgA、IgM、IgG、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05),CD8^(+)低于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论:香菇多糖辅助SOX方案治疗晚期结肠癌疗效确切,能够有效改善化疗所致的免疫功能损伤,减少不良反应,安全性较高。 Objective:To observe the clinical effect of lentinan combined with Sergio and Oxaliplatin scheme for advanced colorectal carcinoma and its effect on immune function.Methods:A total of 58 cases of patients with advanced colorectal carcinoma were divided into the control group and the observation group according to the random number table method,with 29 cases in each group.The control group was treated with SOX scheme,and the observation group was additionally treated with lentinan based on the treatment of the control group.Traditional Chinese medicine(TCM)syndrome scores,and the levels of immunoglobulin and T lymphocyte subsets were compared before and after treatment between the two groups;clinical effects and incidence of adverse reactions in the two groups were evaluated.Results:After treatment,the total effective rate was 68.97%in the control group and 82.76%in the observation group,the difference being significant(P<0.05).After treatment,the scores of TCM syndromes including epigastric pain and fullness,poor appetite and digestion,fatigue and lack of strength,sloppy stool,pale tongue and thin coating in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome scores in the observation group were lower than those in the control group(P<0.05).After treatment,immunoglobulin(Ig)A,IgM,IgG,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+) in the control groups were decreased when compared with those before treatment(P<0.05),and CD8^(+) was increased(P<0.05);IgA,IgM,IgG,CD3^(+),CD4^(+) and CD4^(+)/CD8^(+) in the observation groups were increased when compared with those before treatment(P<0.05),and CD8^(+) was decreased(P<0.05);the IgA,IgM,IgG,CD3^(+),CD4^(+),CD4^(+)/CD8^(+) in the observation group were higher than those in the control group(P<0.05),and the CD8^(+) was lower than that in the control group(P<0.05).Conclusion:Lentinan assisting SOX scheme for advanced colorectal carcinoma has a definite curative effect,and can effectively improve the immune function damage caused by chemotherapy and reduce adverse reactions,with high safety.
作者 牟微娜 邵琰 李肖亮 MOU Weina;SHAO Yan;LI Xiaoliang
出处 《新中医》 CAS 2023年第9期170-173,共4页 New Chinese Medicine
关键词 晚期结肠癌 香菇多糖 替吉奥联合奥沙利铂方案 免疫功能 Advanced colorectal carcinoma Lentinan Sergio and Oxaliplatin scheme Immune function
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