不同提取工艺对复方银杏通脉口服液质量指标的影响

Influence of different extraction processes on quality indices of Compound Yinxing Tongmai oral liquid

目的:探讨不同提取工艺对复方银杏通脉口服液质量指标的影响。方法:采用微波提取、超声提取、醇与水回流提取3种工艺,通过正交试验法对复方银杏通脉口服液的处方进行提取,以总黄酮醇苷、二苯乙烯苷、丹酚酸B含量及干膏率作为考察指标,运用综合评分法进行质量指标的比较。结果:最佳工艺为醇与水回流提取,12倍量料液比,回流提取1 h,提取2次。结论:醇与水回流提取工艺优于微波提取及超声提取工艺,且该方法实际可行,成本可控,可实现大生产。

Objective:To investigate the influence of different extraction processes on the quality indices of Compound Yinxing Tongmai oral liquid.Methods:Based on an orthogonal design,the prescription of Compound Yinxing Tongmai oral liquid was extracted using microwave extraction,ultrasound extraction,and alcohol-water reflux extraction.With total flavonoid glycosides,stilbene glucoside,salvianolic acid B,and dry extract yield as the indicators for assessment,the comprehensive score method was used for comparison of quality indices.Results:The optimal process was alcohol-water reflux extraction,with a solid-liquid ratio of 12 folds,reflux extraction for 1 hour,and extraction twice.Conclusion:Alcohol-water reflux extraction is better than microwave extraction and ultrasound extraction and is practical and feasible with controllable costs,and therefore,it can be used to realize mass production.