中药寡糖研究进展

Oligosaccharides from Chinese Medicinals:A Review

近年来,研究者常从中药药效物质基础这一研究方向出发,通过提取单一植物、动物、矿物中某一类化学成分进行传统中药创新。寡糖是中药中继苷类、多糖以外的又一类活性成分,其聚合度低、极性大、异构体多,分离较困难,但在疾病防治方面却具有巨大潜力。随着技术方法及科研设备的发展,对中药中寡糖成分的研究逐渐增多,其应用范围不断拓展。对近5年中药寡糖相关研究进行综述,主要从其制备方式、纯化分离、药理活性3个方面进行总结,可为中药质量控制和中药创新型新药的开发提供参考。

Aiming at exploring the pharmacodynamic material basis of Chinese medicinals,researchers tend to extract a certain or a category of chemical components from a single plant,animal or mineral for innovation.Besides glycosides and polysaccharides,oligosaccharides are the major active components in Chinese medicinals.Despite the low polymerization,high polarity,diverse isomers,and difficulty in isolation,oligosaccharides show great potential in disease prevention and treatment.Nowadays,amid the advancement of techniques and equipment,there has been an explosion of research on the oligosaccharides from Chinese medicinals.This paper summarizes the research on oligosaccharides from Chinese medicinals in recent five years,particularly the preparation methods,purification and separation,and pharmacological activities.The application in quality control is summed up for the first time.Therefore,this study is expected to serve as a reference for quality control of Chinese medicinals and development of new Chinese medicine.