构建“细胞自噬-气血津液-心肌缺血再灌注损伤”研究思路

Constructing the Research Idea of"Autophagy-qi,Blood and Body Fluid-myocardial Ischemia-Reperfusion Injury"

心肌缺血再灌注损伤(MIRI)的发生发展与气、血、津液这些物质关系密切。生理上气、血、津液为心肌细胞能量代谢的基本物质,病理上这些物质又是损伤心肌细胞功能的基本因素。随着人们对自噬的深入研究,发现自噬在缺血再灌注损伤心肌细胞中的新陈代谢作用与气血津液功能相似。自噬的失调会导致气虚气滞,自噬不足则会导致瘀血和痰饮的堆积。因此,本文通过构建“细胞自噬-气血津液-心肌缺血再灌注损伤”研究思路,从而促进中医药防治MIRI工作取得更大创新和突破。

The occurrence and development of myocardial ischemia-reperfusion injury(MIRI)is closely related to the relationship between qi,blood and body fluid.Physiologically,qi,blood,and body fluid are the basic substances for energy metabolism of myocardial cells,and pathologically,these substances are basic factors that damage the function of myocardial cells.With the in-depth study of autophagy,it was found that the metabolic role of autophagy in ischemia-reperfusion injury myocardial cells is similar to the function of qi,blood and body fluids.The imbalance of autophagy will lead to qi deficiency and stagnation,and the lack of autophagy will lead to the accumulation of blood stasis and phlegm.Therefore,this paper constructs the research idea of"autophagy-qi,blood and body fluid-myocardial ischemia-reperfusion injury",so as to promote greater innovation and breakthrough in the prevention and treatment of MIRI by traditional Chinese medicine.