肝细胞癌合并门静脉癌栓形成机制的研究进展

Research progress on the formation mechanism of hepatocellular carcinoma with portal vein tumor thrombus

肝细胞癌是临床中常见的恶性肿瘤,门静脉癌栓(PVTT)是影响肝细胞癌预后的重要因素之一。PVTT肿瘤学特性较强,极易发生肝外转移,并发门静脉高压,导致消化道出血或肝衰竭,引起死亡。本文通过综述肝细胞癌合并PVTT的局部解剖学、血流动力学、分子生物学及肿瘤微环境方面的形成机制,为临床治疗提供参考。

Hepatocellular carcinoma is a common malignant disease in clinical practice,and portal vein tumor thrombosis(PVTT)is one of the important factors affecting the prognosis of hepatocellular carcinoma.PVTT has strong oncologic characteristics and is highly susceptible to extrahepatic metastasis,complicating portal hypertension,leading to gastrointestinal bleeding or liver failure and causing death.In this paper,we review the formation mechanism of hepatocellular carcinoma combined with PVTT in terms of local anatomy,hemodynamics,molecular biology and tumor microenvironment to provide effective reference for clinical treatment.