艾司西酞普兰对抑郁症患者睡眠状况及BDNF表达水平的影响

Efficacy of Escitalopram on Sleep Status and BDNF Expression Levels in Patients with Depression

目的:探讨艾司西酞普兰对抑郁症患者睡眠状况及BDNF表达水平的影响。方法:选取2021年1月—11月我科就诊的抑郁症患者60例作为研究对象,均给予艾司西酞普兰片口服治疗,观察治疗前后患者的PSG相关指标[睡眠进程、睡眠结构、快速眼动睡眠阶段(REM)睡眠指标],并采用ELISA法测定患者治疗前后血清BDNF表达水平。结果:治疗前后TST比较,差异无统计学意义(P>0.05);治疗后SL、AN、AT低于治疗前,SE高于治疗前,差异有统计学意义(P<0.05)。治疗后S1、S2低于治疗前,SWS高于治疗前(P<0.05),而治疗前后RT比较,差异无统计学意义(P>0.05)。治疗前后RT、RL、RA、RI、RSN、RD、BDNF比较,差异有统计学意义(P<0.05)。结论:艾司西酞普兰片可有效改善抑郁症患者的睡眠质量,同时上调BDNF平均表达水平,有利于改善患者的抑郁症状,促进病情康复。

Objective:Exploring the effect of escitalopram on sleep status and BDNF expression levels in patients with depression.Methods:Sixty patients with depression who were treated in our department from January to November 2021 were selected as the research objects,and they were all treated with escitalopram tablets.The PSG related indexes of patients before and after treatment [ sleep process,sleep structure,fast eye movement sleep stage( REM) sleep index ] were observed,and the serum BDNF expression level of patients before and after treatment was determined by ELISA.Results:There was no significant difference in TST before and after treatment(P>0.05).After treatment,SL,AN and AT were lower than those before treatment,SE was higher than that before treatment,and the difference was statistically significant(P<0.05).After treatment,S1 and S2 were lower than those before treatment,and SWS was higher than that before treatment(P<0.05),while there was no significant difference in RT before and after treatment(P>0.05).There were significant differences in RT,RL,RA,RI,RSN,RD and BDNF before and after treatment(P<0.05).Conclusion:Escitalopram tablets can effectively improve the sleep quality of patients with depression,and increase the average expression level of BDNF,which is conducive to improving the depressive symptoms of patients and promoting the recovery of the disease.