丁苯酞联合阿司匹林口服治疗脑梗死的临床疗效及不良反应分析

Analysis of Clinical Efficacy and Adverse Reactions of Butylphthalide Combined with Aspirin in the Treatment of Cerebral Infarction

目的:探讨丁苯酞联合阿司匹林口服治疗脑梗死的临床疗效及不良反应。方法:选取2019年1月—2022年1月我院接受治疗的脑梗死患者90例作为研究对象,根据用药种类的不同分为对照组(n=45)和治疗组(n=45)。对照组采用阿司匹林进行治疗,治疗组在对照组基础上加用丁苯酞治疗,比较两组临床效果、神经功能、认知水平、不良反应发生率。结果:治疗组治疗总有效率为97.78%,高于对照组的77.78%(P<0.05);治疗组NIHSS评分低于对照组,MMSE评分高于对照组(P<0.05);治疗组简单计算、动作指令、言语能力评分高于对照组(P<0.05);治疗组不良反应发生率低于对照组(P<0.05)。结论:丁苯酞联合阿司匹林口服治疗脑梗死的效果突出,可以改善患者的神经功能、认知水平,且安全性高。

Objective:To investigate the clinical efficacy and adverse reactions of butylphthalide combined with aspirin in the treatment of cerebral infarction.Methods:A total of 90 patients with cerebral infarction who were treated in our hospital from January 2019 to January 2022 were selected as the research objects.According to the different types of medication,they were divided into control group(n=45) and treatment group(n=45).The control group was treated with aspirin,and the treatment group was treated with butylphthalide on the basis of the control group.The clinical effect,neurological function,cognitive level and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the treatment group was 97.78%,which was higher than 77.78% of the control group(P<0.05).The NIHSS score of the treatment group was lower than that of the control group,and the MMSE score was higher than that of the control group(P<0.05).The scores of simple calculation,action instruction and speech ability in the treatment group were higher than those in the control group(P<0.05).The incidence of adverse reactions in treatment group was lower than that in control group(P<0.05).Conclusion:Butylphthalide combined with aspirin is effective in the treatment of cerebral infarction.It can improve the neurological function and cognitive level of patients with high safety.