他达拉非联合心理干预对勃起功能障碍患者不良情绪和血管内皮功能的影响

目的探讨他达拉非联合心理干预治疗勃起功能障碍(ED)的疗效。方法选择2020年6月至2020年12月ED患者60例随机分成对照组(30例)和观察组(30例),对照组给予他达拉非5 mg/d,持续用药3个月;观察组在口服他达拉非药物基础上加以心理干预。分别在治疗3个月和6个月后,比较两组患者的不良情绪和血管内皮功能。结果治疗3个月后,两组患者血管内皮功能指标一氧化氮(NO)、内皮素-1(ET-1)和肱动脉血流介导的血管扩张功能(flow mediated dilation,FMD)均较治疗前改善(P<0.05),但两组间比较差异无统计学意义。不良情绪方面,两组患者治疗后在PHQ-9、GAD-7和IIEF-5评分方面均较治疗前改善(P<0.05),且观察组患者治疗后IIEF-5评分改善优于对照组(P<0.05)。结论他达拉非可以改善患者的血管内皮功能,与心理干预联合还可以明显改善患者的不良情绪。

Objective To investigate the effect of tadalafil combined with psychological intervention on Erectile Dysfunction(ED).Methods A total of 60 male ED patients treated in the Urinary Surgery Department of Tonglu Hospital of Traditional Chinese Medicine from June 2020 to December 2020 were randomly divided into the control group(30 cases)and the observation group(30 cases).The control group was given tadalafil 5 mg/d for 3 months.The observation group received psychological intervention on the basis of oral tadalafil.Poor mood and vascular endothelial function were studied at 3 and 6 months of the treatment.Results After 3 months of the treatment,the vascular endothelial function indexes of nitric oxide(NO),endothelin-1(ET-1)and flow-mediated dilation(FMD)of brhumerus artery in 2 groups were significantly improved compared with before the treatment(P<0.05),but there was no significant difference between 2 groups after the treatment and the improvement value.In terms of poor mood,phQ-9,GAD-7 and IIEF-5 scores in the two groups were significantly improved after the treatment compared with before the treatment(P<0.05),and the improvement of IIEF-5 scores in the psychological intervention combined with tadalafil group was significantly better than that in the tadalafil non-group after the treatment(P<0.05).Conclusion Tadalafil can improve the vascular endothelial function of patients,and the combination with psychological intervention can significantly improve the patients'poor mood.