试从肠黏膜屏障浅谈YFB治疗UC的相关机制

Discussion on the Relevant Mechanism of YFB in the Treatment of UC from the Perspective of Intestinal Mucosal Barrier

以肠黏膜损伤为主的慢性非特异性炎性肠病—溃疡性结肠炎(Ulcerativecolitis,UC),近年来以其发病率的上升而为广大医者所重视。随着中医药对其治疗的研究,发现薏苡附子败酱散(YFB)对UC患者肠黏膜屏障有良好的治疗作用。笔者通过研究发现,肠黏膜机械屏障、生物屏障、免疫屏障、化学屏障其产生UC的相关机制,可以使用YFB对其治疗。且YFB对其的影响可以是单一屏障的影响,也可以是使肠黏膜四大屏障之间相互作用,相互影响,共同构建肠黏膜屏障功能与结构的完整。

Ulcerative colitis(UC),a chronic non-specific inflammatory bowel disease with intestinal mucosa injury as the main feature,has attracted the attention of doctors in recent years due to its increasing incidence rate.With the increasing research onits Traditional Chinese Medicine treatment,it is found that Yiyi Fuzi Baijiangsan(YFB)has a good therapeutic effect on intestinal mucosal barrier in UC patients.Through research,the authors found that the mechanical barrier,biological barrier,immune barrier and chemical barrier of intestinal mucosa can produce the relevant mechanisms of UC,which can be treated with YFB.Moreover,the influence of YFB can be exertedon a single barrier,or induce the interaction and mutual influence of the four barriers,which jointly contribute to the integrity of the intestinal mucosal barrierfunction and structure.