摘要
目的 探讨中药复方治疗脑缺血作用机制的网络药理学研究进展。方法 检索中国知网、PubMed等数据库2005年至2022年的相关文献,分析中药复方治疗脑缺血的作用机制及特点。结果 中药复方治疗脑缺血主要与改善炎性反应、抗氧化应激损伤、抑制神经细胞凋亡、促血管生成、改善凝血等作用机制有关,并通过多成分、多靶点、多通路发挥作用。结论 网络药理学在中药复方治疗脑缺血研究中应用广泛,可为中药复方应用的有效性和科学性提供参考。
Objective To investigate the research progress of the mechanism of Chinese medicine compound preparations in the treatment of cerebral ischemia based on network pharmacology.Methods The relevant studies from databases such as CNKI and PubMed from 2005 to 2022 were searched,and the mechanism and characteristics of Chinese medicine compound preparations in the treatment of cerebral ischemia were analyzed.Results The treatment of cerebral ischemia with Chinese medicine compound preparations was mainly related to the mechanisms such as improving inflammatory response,antioxidant stress damage,inhibiting neuronal apoptosis,promoting angiogenesis,and improving coagulation,and the Chinese medicine compound preparations play their roles through multiple components,targets,and pathways.Conclusion Network pharmacology is widely used in the study of Chinese medicine compound preparations in the treatment of cerebral ischemia,which can provide a reference for the effectiveness and scientificity of the application of Chinese medicine compound preparations.
作者
何瑞华
黄瑾
徐熠
HE Ruihua;HUANG Jin;XU Yi(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai,China 200437)
出处
《中国药业》
CAS
2023年第11期128-128,I0001-I0006,共7页
China Pharmaceuticals
基金
上海中医药大学附属岳阳中西医结合医院科研项目[2019YYZ07]
上海市进一步加快中医药传承创新发展三年行动计划项目[ZY(2021-2023)-0203-03]
上海申康医院发展中心临床科技创新项目[SHDC12021635]。
关键词
网络药理学
中药复方
脑缺血
作用机制
network pharmacology
Chinese medicine compound preparations
cerebral ischemia
mechanism
