摘要
目的 总结空军军医大学西京医院消化内科克罗恩病(CD)患者10年的用药趋势变化。方法 回顾性分析2010—2019年10年间,西京医院IBD中心确诊CD患者的临床一般信息资料、患者用药情况,其中将CD患者根据用药时间段分为2010—2014年组与2015—2019年组,分别分析两组CD患者的一般情况和用药趋势,再根据患者性别和年龄(≤40岁和>40岁)进行亚组分析。结果 2015—2019年组与2010—2014年组分别纳入164和140例CD患者,2010—2014年组和2015—2019年组患者年龄和女性比例比较[(37.2±14.5)岁比(34.7±13.7)岁,30.0%(42/140)比40.9%(67/164)],差异均无统计学意义(P>0.05)。2015—2019年组免疫抑制剂和生物制剂使用率均高于2010—2014年组[50.6%(83/164)比32.1%(45/140)、52.4%(86/164)比23.6%(33/140)],差异均有统计学意义(χ^(2)=10.566、χ^(2)=26.421,P<0.001)。2010—2014年组和2015—2019年组组内女性和男性CD患者的年龄、5-ASA(5-氨基水杨酸)类、激素、免疫抑制剂和生物制剂的使用率比较,差异均无统计学意义(P>0.05)。2015—2019年组组内≥40岁患者生物制剂使用率明显低于<40岁组[34.0%(18/53)比61.3%(68/111)],差异具有统计学意义(P=0.001)。结论 与2010—2014年相比,2015—2019年间,西京医院单中心CD患者数量基本保持稳定,CD患者的生物制剂和免疫抑制剂使用率明显增高;不同性别患者的用药情况基本一致。2015—2019年间,生物制剂使用率增加主要表现为年轻患者(<40岁)使用率增加。
Objective To analyze the trend of medication in patients with Crohn's disease(CD)in the Department of Gastroenterology,Xijing Hospital of Air Force Military Medical University in the past ten years.Methods Clinical data and basic medications of CD patients diagnosed in the IBD Center of Xijing Gastroenterology Hospital from 2010 to 2019were retrospectively analyzed.The CD patients were divided into two groups of 2010-2014 and 2015-2019.The general conditions and medication use trends of the CD patients in two groups were analyzed,including subgroup analysis according to the gender and age of the patients(≤40 years old and 40 years old).Results The number of CD patients was 164 in2015-2019 and 140 in 2010-2014,respectively.The age of patients and proportion of women in the 2010-2014 group and the 2015-2019 group was[(37.2±14.5)vs.(34.7±13.7)and 30.0%(42/140)vs.40.9%(67/164)],both the differences between the two groups were not statistically significant(P>0.05).The use rates of immunosuppressants and biological agents in 2015-2019 were significantly higher than those in 2010-2014[50.6%(83/164)vs.32.1%(45/140)and 52.4%(86/164)vs.23.6%(33/140)],and the differences were both statistically significant.There was no statistically significant difference in the age and use rate of 5-ASA,glucocorticoid,immunosuppressive agents and biologics between female and male CD patients in each group(P>0.05).In the group of 2015-2019,the use rate of biological agents in patients being or over 40 yearsold was significantly lower than that of patients under 40 years old[34.0%(18/53)vs.61.3%(68/111)](P=0.001).Conclusion Compared with 2010-2014,the number of CD patients in our center remains stable,and the use of biological agents and immunosuppressive agents in CD patients increases significantly in 2015-2019.The trend of medication in patients of different genders was basically unanimous.In 2015 to 2019,the use of biological agents in young patients(<40 years old)significantly higher increases.
作者
时艳婷
苏松
薛鲜敏
王芳
周禾
李小飞
杨港
林俊超
吴开春
梁洁
SHI Yan-ting;SU Song;XUE Xian-min;WANG Fang;ZHOU He;LI Xiao-fei;YANG Gang;LIN Jun-chao;WU Kai-chun;LIANG Jie(Department of Gastroenterology,Xijing Hospital,Air Force Medical University,State Key Laboratory of Cancer Biology,National Clinical Research Center for Digestive Diseases,Xi'an 710032,China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2023年第4期296-300,共5页
Chinese Journal of Practical Internal Medicine
基金
国家自然科学基金(81772650,81421003)。
关键词
炎症性肠病
克罗恩病
10年
inflammatory bowel disease
Crohn'disease
ten years