主观认知下降临床研究进展

Clinical research progress on subjective cognitive decline

主观认知下降是患者存在认知功能下降主诉但无客观临床证据的阿尔茨海默病临床前期阶段,被认为是早于轻度认知损害的更早阶段,进展为阿尔茨海默病的风险较高。目前国内对主观认知下降的认知有限,本文从主观认知下降概念、流行病学、研究框架、相关影响因素、与阿尔茨海默病关系,以及神经心理学测验、影像学研究进展进行综述,为临床早期诊断阿尔茨海默病提供可能。

Subjective cognitive decline(SCD)refers to the preclinical stage of Alzheimer's disease(AD)in which patients have the chief complaint of cognitive decline but no objective manifestations.It is considered to be an earlier stage of mild cognitive impairment(MCI)than the preclinical stage of AD,and the risk of progression to AD is higher.At present,there is a limited understanding of SCD in China.This paper reviews the concept of SCD,the status quo of epidemiological research,research framework,related risk factors,its relationship with AD,as well as the progress of neuropsychological tests and imaging research,so as to provide the possibility for the early clinical diagnosis and treatment of AD.