睑板腺疏通联合玻璃酸钠滴眼液治疗儿童干眼症50例临床观察

Clinical observation on 50 cases of dry eyes syndrome in children treated by meibomian gland dredging combined with sodium hyaluronate eye drops

目的 观察睑板腺疏通联合玻璃酸钠滴眼液治疗儿童干眼症的临床疗效。方法 将100例干眼症患儿采用随机数字表法分为对照组和治疗组,各50例。对照组予玻璃酸钠滴眼液治疗,治疗组予睑板腺疏通联合玻璃酸钠滴眼液治疗。治疗4周后比较2组的临床疗效和不良反应发生情况,以及治疗前后的泪膜破裂时间(BUT)、Schirmer I试验(SIT)值、眼表疾病指数(OSDI)、睑板腺评分、角膜荧光素染色(FL)评分。结果 对照组总有效率为64%(32/50),治疗组为88%(44/50),2组比较差异有统计学意义(P<0.01);治疗后2组BUT明显延长,SIT值明显升高,OSDI、睑板腺评分、FL评分明显降低,与同组治疗前比较差异均有统计学意义(P<0.01),且治疗组改善更明显,与对照组治疗后比较差异均有统计学意义(P<0.01);2组治疗过程中均未发生明显不良反应。结论 睑板腺疏通联合玻璃酸钠滴眼液治疗儿童干眼症具有良好的临床疗效,可以疏通睑板腺,稳定泪膜,缓解角膜干燥,且无明显不良反应,患儿依从性高,值得临床推广应用。

Objective To observe the clinical efficacy of meibomian gland dredging combined with sodium hyaluronate eye drops in the treatment of dry eye in children. Methods 100 children with dry eye syndrome were randomly divided into a control group and a treatment group by the random number table method, with 50 cases in each group. The control group was treated with sodium hyaluronate eye drops, while the treatment group was treated with meibomian gland dredging combined with sodium hyaluronate eye drops. After 4 weeks of treatment, the clinical efficacy and incidence of adverse reactions between the two groups were compared, as well as the tear film break-up time(BUT),Schirmer I test(SIT) values, ocular surface disease index(OSDI),meibomian gland score, and corneal fluorescence staining(FL) score before and after treatment.Results The total effective rate of the control group was 64%(32/50),while that of the treatment group was 88%(44/50). The difference between the two groups was statistically significant(P<0.01);After treatment, the BUT and SIT values of the two groups significantly increased, while the OSDI,meibomian gland score, and FL score significantly decreased. There were statistically significant differences compared to the same group before treatment(P<0.01),and the improvement was more significant in the treatment group. There were statistically significant differences compared to the control group after treatment(P<0.01).No significant adverse reactions occurred during the treatment of both groups. Conclusion The combination of meibomian gland dredging and sodium hyaluronate eye drop is clinically effective in the treatment of dry eye in children. It can clear the meibomian gland, stabilize the tear film, alleviate corneal dryness, and have no obvious adverse reactions, and is easier accepted by children, so it is worth promoting and applying in clinical practice.