马明团队在多环倍半萜形成机制和结构多样性扩展方面取得新进展

The research team of Prof.Ming Ma has made new progress in the formation mechanism and structural diversity expansion of Polycyclic Sesquiterpenes

2023年4月5日,北京大学药学院天然药物及仿生药物国家重点实验室马明团队在JACS上发表了题为“Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis”的研究论文。该研究阐明了三种三环倍半萜环化酶的晶体结构和催化机制,并通过环化酶的理性改造扩展倍半萜结构多样性。