摘要
华支睾吸虫主要寄生于人的肝胆管内,虫体在胆管内的长期寄生会导致肝胆管慢性炎症,引起胆管上皮增生,进而导致胆管周围纤维化。本文通过从虫体的固有免疫、适应性免疫对华支睾吸虫感染所致纤维化在免疫学方面的研究进展进行阐述。
Clonorchis sinensis mainly parasitizes in human hepatobiliary duct,long-term parasitism of C.sinensis in bile duct will lead to chronic inflammation of hepatobiliary duct,hyperplasia of bile duct epithelium and then fibrosis around bile duct.This paper reviews research on the immunology of fibrosis caused by C.sinensis infection from the aspects of innate immunity,adaptive immunity.
作者
赵磊
彭小红
ZHAO Lei;PENG Xiaohong(Department of Parasitology,Guilin Medical College,Guilin 541004,China;Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair,the Affiliated Hospital of Guilin Medical University;Guangxi University Key Laboratory of Pathogenic Biology)
出处
《中国病原生物学杂志》
CSCD
北大核心
2023年第5期609-613,共5页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.82060376)。
关键词
华支睾吸虫
肝吸虫
纤维化
免疫
综述
Clonorchis sinensis
liver fluke
fibrosis
immunology
review
