HIV潜伏病毒库清除策略的研究进展

Research advance in the strategies for clearing latent viral reservoir of HIV

艾滋病是严重危害人体健康的慢性传染性疾病,目前尚无有效疫苗和根治药物。HIV潜伏病毒库的存在是体内病毒不能被彻底清除的主要障碍,如何清除HIV潜伏病毒库是现阶段艾滋病治愈的研究热点。本文通过阐述HIV潜伏病毒库的形成及维持机制、存储位置、检测方法、清除策略等方面的研究进展,旨为艾滋病功能性治愈的研究提供新思路。

AIDS is a chronic infectious disease that seriously endangers human health,and there is no effective vaccine and radical drug at present.The existence of HIV latent virus reservoir is the main obstacle that the virus can't be completely eliminated in vivo.Therefore,how to clear the latent virus reservoir is the focus of AIDS cure research at this stage.In this paper,the research progress of the formation and maintenance mechanism,storage location,detection methods and clearance strategies of HIV latent virus reservoir are described,which aims to provide new ideas for the research of functional cure of AIDS.