类胡萝卜素立体异构体构效关系及其应用研究进展

Structure-Activity Relationship and Applications of Carotenoids Stereoisomers:A Review

类胡萝卜素是水果、蔬菜等膳食原料中广泛存在的天然色素,由于分子中存在大量的共轭双键,类胡萝卜素能形成较多的立体异构体。果蔬中天然存在的类胡萝卜素主要为全反式构型,但人体中检测到的类胡萝卜素顺式异构体占比较高。因此,全反式类胡萝卜素的构型转化,类胡萝卜素的空间构型与生理活性的关系引起了研究人员的关注。作者通过文献查阅、产品调研、国内外法规比较,综述了类胡萝卜素顺式异构体的制备方法、不同异构体的检测分析方法、稳定性评价、生理活性及应用的研究进展,为进一步研究类胡萝卜素的空间构型及其应用提供参考。

Carotenoids are pigments widely found in fruits and vegetables.There are many stereoisomers of carotenoids due to the large number of conjugated double bonds present in the molecules.The natural carotenoids in fruits and vegetables mainly exist in all-trans(E)configuration.However,the proportion of cis-isomers of carotenoids detected in human bodies is high.Configuration transformation of all-E-carotenoids,and the relationship between isomer types and bioactivities of carotenoids have attracted the attention of scholars.Through literature and product research,domestic and international regulations comparison,this study reviews preparation of cis-isomers,the detection and analysis of various isomers,stability evaluation,physiological activity and application of carotenoid isomers,providing a reference for the further study on configurations of carotenoids and their application.