子宫微生物群与女性不孕不育关系研究进展

Research Progress on the Relationship between Uterine Microbiota and Female Infertility

女性不孕不育病因复杂,保持生殖道健康的关键是生态菌群处于稳定状态,菌群稳态失衡会诱发生殖道感染,并导致女性不孕不育。随着子宫微生物群的研究深入及新一代微生物测序技术的发展,越来越多的证据显示子宫微生物群会对宿主生育能力产生影响。对近年来有关子宫微生物群及其与女性不孕不育的相关性研究进行综述,以期为不孕不育的诊疗提供新思路。

The etiology of female infertility is complex and diverse.Stable ecological flora is the key to reproductive tract health,and imbalance of flora ratio will lead to reproductive tract infection and female infertility.With the development of uterine microbiota research and next-generation microbial sequencing technology,more and more evidence shown that uterine microbiota may affect host fertility.The recent studies on uterine microbiota and its correlation with female infertility are reviewed,in order to provide new ideas for the diagnosis and treatment of infertility patients.