基于血清铁蛋白、铁水平分析其在精神病患者及健康群体的差异及与NAFLD的关系研究

To analyze the differences of serum ferritin and iron levels in patients with mental illness and healthy people and their relationship with NAFLD

目的:探讨血清铁蛋白(SF)及铁水平在精神病患者及健康群体中的差异并分析其于非酒精性脂肪肝(NAFLD)的关系。方法:回顾性分析2022年4月-2022年7月经我院确诊伴有精神类疾病的126例患者的临床资料并将其纳入精神组,另选取53例来我院行一般体检的健康患者作为健康组,采用电化学发光法检测两组患者SF及铁水平;根据B超结果将精神组分为精神NAFLD组(n=59)与精神N-NAFLD组(n=67),将健康组分为健康NAFLD组(n=25)与健康N-NAFLD组(n=28),对比四组SF及铁水平差异;采用Speraman相关系数分别分析SF及铁水平在精神组与健康组中与NAFLD发生的相关性;绘制ROC曲线分别分析SF及铁水平检测在精神组及健康组中对NAFLD发生的诊断效能。结果:精神病组患者的SF及铁水平均显著高于健康群体(P<0.05),同时各组内NAFLD患者的SF及铁水平均高于N-NAFLD患者(P<0.05);通过Speraman相关系数显示SF及铁水平与NAFLD发病之间呈显著的正相关关系(P<0.05);ROC显示SF及铁水平联合检测不管是在精神病患者还是健康群体中其诊断效能均高于单一检测,其在健康群体中检测NAFLD的敏感度为87.40%、特异度为83.20%,在精神病患者中检测NAFLD的敏感度为88.20%、特异度为80.50%。结论:在精神病患者及NAFLD患者中均能观察到血清铁及SF显著增高的情况,通过以上两项指标检测能够为不同患病群体诊断NAFLD提供重要的参考借鉴。

Objective:To investigate the differences of serum ferritin(SF)and iron levels in psychiatric patients and healthy people,and to analyze the relationship between serum ferritin(SF)and non-alcoholic fatty liver disease(NAFLD).Methods:The clinical data of 126 patients diagnosed with psychiatric disorders in our hospital from April 2022 to July 2022 were retrospectively analyzed and included in the psychiatric group.Another 53 healthy patients who underwent general physical examination in our hospital were selected as the healthy group.The SF and iron levels of the two groups were detected by electrochemiluminescence.According to the results of B-ultrasound,the mental group was divided into mental NAFLD group(n=59)and mental N-NAFLD group(n=67),and the healthy group was divided into healthy NAFLD group(n=25)and healthy N-NAFLD group(n=28).The differences in SF and iron levels among the four groups were compared.Spearman correlation coefficient was used to analyze the correlation between SF and iron levels and the occurrence of NAFLD in mental and healthy groups.ROC curve was drawn to analyze the diagnostic efficacy of SF and iron level detection in the occurrence of NAFLD in the psychiatric group and the healthy group.Results:The average SF and molten iron of patients with mental illness were significantly higher than those of healthy subjects(P<0.05),and the average SF and molten iron of patients with NAFLD were significantly higher than those of patients with N-NAFLD in each group(P<0.05).Speraman correlation coefficient showed that SF and iron levels were positively correlated with the incidence of NAFLD(P<0.05).ROC showed that the combined detection of SF and iron level had a higher diagnostic efficiency than single detection in both psychiatric patients and healthy people.The sensitivity and specificity of SF and iron level in the detection of NAFLD in healthy people were 87.40%and 83.20%,and the sensitivity and specificity in the detection of NAFLD in psychiatric patients were 88.20%and 80.50%.Conclusion:Serum iron and SF levels can be significantly increased in both mental patients and NAFLD patients.The detection of the above two indexes can provide important reference for the diagnosis of NAFLD in different patients.