降尿酸方治疗尿酸性肾病疗效及对NLRP3信号通路的影响

Effect of Jiang Niaosuan Formula(降尿酸方) on Uric Acid Nephropathy and NLRP3 Signaling Pathway

目的:探讨降尿酸方对尿酸性肾病患者的疗效,及对核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)信号通路的影响。方法:将168例尿酸性肾病患者以随机数字表法分为观察组(降尿酸方联合非布司他片治疗)和对照组(非布司他片治疗)各84例。比较两组临床疗效及治疗前后中医证候积分、肾功能指标、血脂、载脂蛋白A1、载脂蛋白B、NLRP3信号通路水平变化,观察不良反应情况。结果:治疗后,总有效率观察组91.67%,对照组80.95%,观察组疗效优于对照组(P<0.05);治疗后,两组中医证候积分、肾功能指标、血脂、载脂蛋白、NLRP3信号通路水平均有所改善(P<0.05),且组间比较,差异均有统计学意义(P<0.05);治疗后,两组不良反应发生情况比较,差异有统计学意义(P<0.05)。结论:降尿酸方可能通过NLRP3信号通路治疗尿酸性肾病,可改善患者肾功能、血脂及载脂蛋白水平,安全性高。

Objective:To investigate the effect of Jiang Niaosuan Formula(降尿酸方)on uric acid nephropathy and its effect on NOD-like receptor protein 3(NLRP3)signaling pathway.Methods:A otal of 168 patients with uric acid nephropathy were divided into observation group(Jiang Niaosuan Formula combined with Febuxostat)and control group(Febuxostat)by random number table method,with 84 cases in each group.The clinical efficacy and the changes of traditional Chinese medicine(TCM)syndrome score,renal function index,blood fat,apolipoprotein A1,apolipoprotein B and NLRP3 signaling pathway before and after treatment were compared between the two groups,and the adverse reactions were observed.Results:After treatment,the total effective rate was 91.67%in the observation group and 80.95%in the control group.The curative effect of the observation group was better than that of the control group(P<0.05).After treatment,TCM syndrome score,renal function index,blood fat,apolipoprotein and NLRP3 signaling pathway levels in the two groups were improved(P<0.05),and the differences between groups were statistically significant(P<0.05).After treatment,there was statistical significance in the occurrence of adverse reactions between the two groups(P<0.05).Conclusion:Jiang Niaosuan Formula may treat uric acid nephropathy through NLRP3 signaling pathway,and can improve renal function,blood fat and apolipoprotein level in patients with uric acid nephropathy with high security.