rs-fMRI在针刺改善中医烦躁焦虑状态研究中的应用现状

Research Progress of Using Resting State Functional Magnetic Resonance Imaging in Studying Mechanism Underlying Treating Anxiety and Irritability State in Traditional Chinese Medicine with Acupuncture

“中医烦躁焦虑状态”是一种以焦虑不安、刚躁易怒为主要表现的异常心理状态。针刺治疗中医烦躁焦虑状态疗效肯定,而静息态功能磁共振成像(rs-fMRI)技术凭借无创性、高空间分辨率等优势已成为研究其脑效应中枢机制的有效方法。通过回顾近年来国内外的研究成果,从局部一致性分析、低频振幅分析、脑区功能连接等rs-fMRI常用分析方法入手,总结了rs-fMRI在针刺治疗失眠焦虑状态、疼痛相关不良心理状态、抑郁症等中医烦躁焦虑状态相关病症研究中的应用现状,并对进一步的多学科多维度深入研究作出展望,以期为今后研究提供参考和借鉴。参考文献57篇。

“Irritability and anxiety state in traditional Chinese medicine(TCM)”is an abnormal psychological disorder with anxiety and irritability as the major manifestations.Acupuncture is effective in the treatment of irritability and anxiety state in TCM.Resting state functional magnetic resonance imaging(rs-fMRI)is an effective method to study the underlying mechanism because of its advantages such as non-invasive and high spatial resolution.By reviewing recent research results in China and abroad,starting from the common analysis methods of rs-fMRI such as local consistency analysis,low-frequency amplitude analysis,and functional connection of brain regions,the application status of rs-fMRI in the treatment of insomnia,anxiety,pain-related adverse psychological state,depression and other diseases related to irritability and anxiety in TCM was summarized,and the prospects of multidisciplinary and multi-dimensional in-depth research was also explored,so as to provide references for future research.Fifty seven research papers are cited as references.