摘要
通过在商用ZA6-1锌合金表面沉积负载十二烷基硫酸钠(SDS)和乙酰丙酸(LA)的聚乳酸羟基乙酸共聚物(PLGA)赋予其抗菌性能。首先,在ZA6-1锌合金表面聚合化沉积APTES接枝层,获得氨基官能团;随后,利用氨基官能团与羧基官能团的正负电荷吸引作用使与SDS/LA混合的PLGA负载于基体表面。所制备的PLGA−SDS/LA涂层具有良好的耐腐蚀能力,其腐蚀速率低至0.005 mm/a,并且可通过改变涂层厚度对其进行调控。该涂层除具有良好的成骨细胞相容性外,还具有优良的抗菌性能,其对金黄色葡萄球菌和大肠杆菌的抗菌率分别达到98.9%和99.8%。
The commercial zinc aluminum alloy(ZA6-1)surface was functionalized with poly-(lactic-co-glycolic)acid(PLGA)containing sodium dodecyl sulfate(SDS)and levulinic acid(LA)for gaining antibacterial activity.A polymerized 3-aminopropyltriethoxysilane(APTES)layer was initially fabricated on the surface of ZA6-1 alloy to gain amino group,and the PLGA mixed with SDS/LA was subsequently immobilized on the as-treated surface through the electrostatic interaction between amino group and carboxyl group.The PLGA−SDS/LA coating on zinc alloy showed extremely good corrosion resistance with the degradation rate of 0.005 mm/a,which can be adjusted by varying the coating thickness.Furthermore,besides the good biocompatibility to osteoblasts,the PLGA−SDS/LA coating exhibited excellent antibacterial property,and the bactericidal rates against Staphylococcus aureus and Escherichia coli were 98.9%and 99.8%,respectively.
作者
赵德人
陈栋
封雪
陈滋霖
金宸
谭小东
向芸颉
焦文博
方亚星
徐立群
张永平
饶席
De-ren ZHAO;Dong CHEN;Xue FENG;Zi-lin CHEN;Chen JIN;Xiao-dong TAN;Yun-jie XIANG;Wen-bo JIAO;Ya-xing FANG;Li-qun XU;Yong-ping ZHANG;Xi RAO(School of Materials and Energy,Southwest University,Chongqing 400715,China;Chongqing Key Laboratory of Soft-matter Material Chemistry and Function Manufacturing,Southwest University,Chongqing 400715,China;School of Food Science,Southwest University,Chongqing 400715,China;Department of Clinical Laboratory,University-Town Hospital of Chongqing Medical University,Chongqing 401331,China)
基金
National Natural Science Foundation of China(No.51801164)
the Fundamental Research Funds for the Central Universities,China(No.XDJK2020C005)
Chongqing Key Laboratory Fund of Soft-matter Material Chemistry and Function Manufacturing,China(No.20200006)
Chongqing College Student Innovation and Entrepreneurship Program of Southwest University,China(No.202010635076).
关键词
锌合金
聚合物涂层
抗菌性能
生物相容性
腐蚀行为
zinc alloy
polymer coating
antibacterial property
biocompatibility
corrosion behavior
