不同时相中微管蛋白对细胞周期蛋白的调控作用

The Tubulin Regulate the Cell Cyclin in Different Phases

在所有真核生物中微管主要以结构性骨架蛋白存在,参与有丝分裂、细胞运动和细胞内运输等关键的细胞过程。在动物细胞中,微管在不同时相中聚合或解聚的周期性转变可以影响纺锤体的形成和细胞的分裂,调控细胞周期的进程。该文主要总结细胞周期不同时相中哺乳动物微管蛋白在不同处理条件下的变化,分别阐述微管蛋白在细胞周期的G0期、S期和G2/M期的重要作用,进一步地完善微管蛋白在哺乳动物细胞周期中的功能,为以后分析微管在细胞周期特定阶段中的作用提供参考依据。

The microtubules are predominantly structural skeleton proteins involved in key cellular processes such as mitosis,cell motility,and intracellular trafficking in eukaryotes.In animal cells,periodic transitions in the aggregation or depolymerization of microtubules in different phases can affect the formation of spindles and the division of cells,thereby regulating the progress of the cell cycle.In this paper,the changes of mammalian tubulin in different phases of cell cycle under different treatment conditions were summarized,and the important role of tubulin in G0 phase,S phase and G2/M phase of cell cycle was expounded respectively,which further improved the function of tubulin in mammalian cell cycle and provided reference for the analysis of the role of microtubules in specific stages of cell cycle.