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白细胞介素-10的免疫双重作用及抗炎应用进展 被引量:2

ADVANCES IN THE DUAL IMMUNOREGULATORY ROLE OF INTERLEUKIN-10 AND ITS APPLICATION IN ANTI-INFLAMMATION
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摘要 白细胞介素-10(IL-10)是抗炎细胞因子,近年来,大量研究显示IL-10兼具免疫刺激和免疫抑制的双重作用。本文分析了IL-10发挥双重免疫调节作用的机制与主要抗炎作用通路,综述了IL-10在炎性疾病中的治疗潜力及IL-10的药物开发方向。 Interleukin-10(IL-10)is an anti-inflammatory cytokine,and in recent years,a large number of studies have shown that IL-10 has the dual role of immunostimulation and immunosuppression.This article analyzes the mechanism of the dual immunoregulatory role of IL-10 and the main anti-inflammatory pathways of IL-10 and reviews the therapeutic potential of IL-10 in inflammatory diseases and the future direction for drug development.
作者 王贞丽 秦欢 王建刚 丁会芹 WANG Zhenli;QIN Huan;WANG Jiangang;DING Huiqin(Quality Management Section of Qingdao Special Service Sanatorium Center of PLA Navy,Qingdao 266071,China)
出处 《青岛大学学报(医学版)》 CAS 2023年第2期313-316,共4页 Journal of Qingdao University(Medical Sciences)
基金 山东省新旧动能转换重大工程重大课题攻关项目(鲁发改重大办[2018]1268号) 山东省重大科技创新工程项目(2018CXGC1404)。
关键词 白细胞介素10 免疫调节 炎症 基因治疗 interleukin-10 immunomodulation inflammation genetic therapy
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