甘肃产黄芪重金属含量特征分析及健康风险评估

Analysis of heavy metal content and health risk assessment of Astragalus membranaceus in Gansu province

目的:了解甘肃主产区黄芪中重金属污染情况,并对食用黄芪中潜在的健康风险进行评估。方法:采用随机抽样的方法,使用电感耦合等离子体质谱仪(ICP-MS)法测定黄芪中Pb、Cd、As、Hg、Cu 5种重金属元素含量,并结合每日最大可耐受摄入量(EDI)、靶标危害系数(THQ)和终身致癌性风险(LCR)进行健康风险评估。结果:58批次黄芪样品中Pb、Cd、As、Hg、Cu元素的平均含量分别为0.148,0.024,0.139,0.011,4.569 mg/kg,但均未超标。健康风险评估模型EDICu>Pb>Hg>Cd,且均<1;LCR值<1×10^(-6),表明黄芪样本总体水平是安全的。结论:甘肃主产地黄芪中5种重金属含量对成人和儿童健康不存在潜在风险。

Objective:This study aimed to investigate the pollution of heavy metals in Astragalus membranaceus in the main producing areas of Gansu,and to evaluate the potential health risks of edible Astragalus membranaceus.Methods:The contents of five heavy metal elements Pb,Cd,As,Hg and Cu in Astragalus membranaceus were determined by inductively coupled plasma mass spectrometer(ICP-MS)by random sampling method,and the data were analyzed.Estimated Daily Intake(EDI),Target Hazard Factor(THQ)and Lifetime Carcinogenicity Risk(LCR)were used for health risk assessment.Results:The average contents of Pb,Cd,As,Hg,and Cu elements in 58 batches of Astragalus membranaceus samples were 0.148,0.024,0.139,0.011 and 4.569 mg/kg,respectively.According to the limited standards stipulated in the 2020 edition of the Chinese Pharmacopoeia,although the detection rate of individual elements was high,but none of them exceeds the standard.The health risk assessment model showed that EDI<PTDI,the order of THQ was As>Cu>Pb>Hg>Cd,and all less than 1,LCR was also less than 1×10^(-6).Indicated that the overall level of Astragalus membranaceus samples in this study was safe.Conclusion:The content of five heavy metals in Astragalus membranaceus produced in Gansu will not cause potential risks to the health of adults and children,and there is no potential carcinogenic risk.