环状电极电脉冲消融下心肌组织电场分布仿真结果与分析

Simulation Results and Analysis of Electric Field Distribution in Myocardial Tissue under Circular Electrode Electric Pulse Ablation

电脉冲消融作为一种心房颤动新的消融能源,具有更高的组织选择性以及生物安全性,因此应用前景广阔。目前有关多极电极进行组织学电脉冲仿真消融的研究非常有限。在COMSOL5.5平台构建肺静脉环状多电极消融模型进行仿真研究。研究结果显示,当电压幅值达到约900 V即可使得部分位置达到透壁性消融,而电压幅值达到1 200 V形成的连续消融区域深度可达3 mm。当增加导管电极与心肌组织间距为2 mm时,至少需要约2 000 V的电压使连续消融区域深度达3 mm。通过环状电极电脉冲消融仿真,该研究结果可为电脉冲消融的临床应用时的电压选择提供参考。

As a new energy source for atrial fibrillation ablation,electric pulse ablation has higher tissue selectivity and biosafety,so it has a great application prospect.At present,there is very limited research on multielectrode simulated ablation of histological electrical pulse.In this study,a circular multi-electrode ablation model of pulmonary vein will be built on COMSOL5.5 platform for simulation research.The results show that when the voltage amplitude reaches about 900 V,it can make some positions achieve transmural ablation,and the depth of continuous ablation area formed can reach 3 mm when the voltage amplitude reaches 1200 V.When the distance between catheter electrode and myocardial tissue is increased to 2 mm,a voltage of at least 2000 V is required to make the depth of continuous ablation area reach 3 mm.Through the simulation of electric pulse ablation with ring electrode,the research results of this project can provide reference for the voltage selection in the clinical application of electric pulse ablation.