Gal-3、hs-CRP及BNP在急性心肌梗死并发恶性室性心律失常患者中的应用价值

Application value of Gal⁃3,hs⁃CRP and BNP in the patients with acute myocardial infarction complicated with malignant ventricular arrhythmia

目的探讨急性心肌梗死(AMI)合并恶性室性心律失常(MVA)患者半乳凝素-3(Gal-3)、高敏C反应蛋白(hsCRP)及B型脑钠肽(BNP)水平及三者与AMI合并MVA的关系。方法选取儋州市人民医院2019年7月至2021年11月收治的AMI患者130例,根据其是否并发MVA分为并发症组(27例),无并发症组(103例),比较2组患者Gal-3、hs-CRP及BNP水平差异,分析AMI合并MVA患者与Gal-3、hs-CRP及BNP水平的关系。采用单因素、多因素分析方法分析AMI合并MVA的影响因素,受试者操作特征(ROC)曲线分析Gal-3、hs-CRP、BNP水平单独、联合对AMI合并MVA的预测价值。结果并发症组患者Gal-3、hs-CRP及BNP水平高于无并发症组,差异有统计学意义(P<0.05)。Gal-3、hs-CRP及BNP水平与AMI并发MVA存在正相关性(r=0.684、0.406、0.211,P<0.05)。多因素、单因素分析可知,Gal-3、hs-CRP及BNP水平、年龄、心功能分级、血管病变支数是AMI并发MVA的影响因素。Gal-3、hs-CRP及BNP单独、联合预测AMI并发MVA曲线下面积为0.789、0.650、0.987、0.991。结论AMI合并MVA患者Gal-3、hs-CRP及BNP水平均有异常升高,且Gal-3、hs-CRP及BNP是AMI合并MVA的危险因素,对AMI患者是否合并MVA有一定评估价值。

Objective To investigate the changes of galectin‑3(Gal‑3),high‑sensitivity C‑reactive protein(hs‑CRP)and Btype brain natriuretic peptide(BNP)in the patients with acute myocardial infarction(AMI)complicated with malignant ventricular arrhythmia(MVA)and their relationship with AMI complicated with MVA.Methods 130 AMI patients admitted in Danzhou People's Hospital from July 2019 to November 2021 were randomly selected as research subjects,and were divided into the complication group(27 cases)and non‑complication group(103 cases),depending on whether or not they were complicated with MVA.The differences in the levels of Gal‑3,hs‑CRP and BNP were compared between the two groups,and the relationship between Gal‑3,hs‑CRP and BNP levels in the patients with AMI complicated with MVA was analyzed as well.Univariate and multivariate analyses were used to analyze the influencing factors of AMI combined with MVA,and ROC curve was used to analyze the predictive value of Gal‑3,hs‑CRP and BNP levels alone and collectively on AMI combined with MVA.Results The levels of Gal‑3,hs‑CRP and BNP in the complication group was significantly higher than that in the non‑complication group,with statistical significance(P<0.05).Gal‑3,hs‑CRP and BNP were positively correlated with AMI complicated with MVA(r=0.684,0.406,0.211,and P<0.05).Multivariate and univariate analyses showed that Gal‑3 level,hs‑CRP,BNP,age,cardiac function classification and the number of vascular lesions were influencing factors of AMI complicated with MVA.The areas under the curve for single or joint prediction of AMI complicated with MVA by Gal‑3,hs‑CRP and BNP were respectively 0.789,0.650,0.987 and 0.991.Conclusion The levels of Gal‑3,hs‑CRP and BNP in the patients with AMI complicated with MVA all elevate abnormally,and Gal‑3,hs‑CRP and BNP are independent risk factors of AMI complicated with MVA.For this reason,it has a certain value in the evaluation of AMI patients complicated with MVA.