碳纳米碎片-镍修饰电极电化学检测硝苯地平的研究

Carbon Nano-fragments and Nickel Glass Carbon Electrode for the Electrochemical Detection of Nifedipine

通过溶胶-凝胶热还原法制备碳纳米碎片-镍(CNF-Ni)复合材料,用于玻碳电极的修饰,构建硝苯地平电化学传感器(CNF-Ni/GCE)。通过扫描电子显微镜、X射线衍射、红外光谱和电化学技术研究CNF-Ni/GCE电极的形貌和催化特性。结果表明:CNF-Ni/GCE修饰电极对硝苯地平具有良好的催化性能。在优化实验条件的基础上,利用差分脉冲伏安技术测定,硝苯地平浓度在4~160μmol/L范围内与其氧化峰电流呈良好的线性关系,检出限为2μmol/L。该方法可用于实际药品中硝苯地平的检测。

Carbon nano-fragments-nickel(CNF-Ni)composites were synthesized by sol-gel thermal reduction method for the modification of glassy carbon electrodes and applied in the electrochemical sensor construction of nifedipine.The morphology and catalytic characteristic of CNF-Ni/GCE electrode were studied employing field emission scanning electron microscope,X-ray diffraction,fourier infrared spectrometer,and electrochemical technology.The results indicated that CNF-Ni/GCE electrode exhibited favourable electrocatalytic performance for nifedipine determination.Under the optimal conditions,using differential pulse voltammetry(DPV),the linear relationship between anode peak current and nifedipine concentrations was obtained from 4 to 160μmol/L,and the detection limits was 2μmol/L.The proposed method was employed to determine nifedipine in the actual drug detection.