血清TC、TG及ox-LDL水平与急性非心源性脑梗死患者颈动脉易损斑块的相关性

Relationship between serum TC,TG,and ox-LDL levels and vulnerable carotid plaque in patients with acute non-cardiogenic cerebral infarction

目的 探讨血清胆固醇(TC)、甘油三酯(TG)及氧化型低密度脂蛋白(ox-LDL)水平与急性非心源性脑梗死患者颈动脉易损斑块的相关性。方法 103例急性非心源性脑梗死患者依据颈动脉斑块稳定性分为稳定组(n=61)与易损组(n=42)。比较两组基础资料信息及实验室指标差异,通过多因素Logistic回归分析明确颈动脉易损斑块形成的危险因素。结果 易损组合并糖尿病、高血压、高脂血症患者占比显著高于稳定组,血清TC、TG、低密度脂蛋白胆固醇(LDL-C)、ox-LDL水平显著高于稳定组,而血清高密度脂蛋白胆固醇(HDL-C)水平显著低于稳定组,差异有统计学意义(P<0.05)。经受试者工作特征曲线(ROC)分析证实血清TC、TG、LDL-C、HDL-C、ox-LDL均能用于急性非心源性脑梗死患者颈动脉易损斑块形成的预测,且均有P<0.05。经多因素Logistic回归分析证实,合并糖尿病、高血压、高脂血症及TC≥5.455 mmol/L、TG≥1.305 mmol/L、LDL-C≥2.655 mmol/L、HDL-C≤1.230 mmol/L、ox-LDL≥457.765μg/L均为急性非心源性脑梗死患者颈动脉易损斑块形成的危险因素(P<0.05)。结论 急性非心源性脑梗死患者颈动脉易损斑块形成受到诸多因素的影响,其中TC、TG、ox-LDL易损斑块形成关系密切。

Objective To investigate the relationship between serum total cholesterol(TC),triglyceride(TG),and oxidized low-density lipoprotein(ox-LDL)levels and vulnerable carotid plaques in patients with acute non-cardiogenic cerebral infarction.Methods According to the stability of carotid plaques,103 patients with acute non-cardiogenic cerebral infarction were divided into stable group(n=61)and vulnerable group(n=42).The basic data and laboratory indicators of the two groups were compared.A multivariable logistic regression analysis was used to determine risk factors for the formation of vulnerable carotid artery plaques.Results Compared with the stable group,the vulnerable group showed significantly higher proportions of diabetes mellitus,hypertension,and hyperlipidemia,significantly higher levels of serum TC,TG,ox-LDL,and low-density lipoprotein cholesterol(LDL-C),and a significantly lower level of serum high-density lipoprotein cholesterol(HDL-C)(all P<0.05).The receiver operating characteristic curve analysis revealed that serum TC,TG,LDL-C,HDL-C,and ox-LDL could all be used to predict the formation of vulnerable carotid plaques in patients with acute non-cardiac cerebral infarction(all P<0.05).The multivariable logistic regression analysis demonstrated that diabetes mellitus,hypertension,hyperlipidemia,TC≥5.455 mmol/L,TG≥1.305 mmol/L,LDL-C≥2.655 mmol/L,HDL-C≤1.230 mmol/L,and ox-LDL≥457.765μg/L were risk factors for vulnerable carotid plaques in patients with acute non-cardiogenic cerebral infarction(all P<0.05).Conclusion Various factors can drive the formation of vulnerable carotid plaques in patients with acute non-cardiogenic cerebral infarction.TC,TG,and ox-LDL are closely related to vulnerable plaque formation.