血清纤维蛋白原与白蛋白比值与缺血性脑血管病的相关性研究

Correlation between serum fibrinogen albumin ratio and ischemic cerebrovascular disease

目的 分析治疗前血清纤维蛋白原与白蛋白比值(FAR)与缺血性脑血管病(IVD)以下主要类型:腔隙性脑梗死(LI)、短暂性脑缺血发作(TIA)的相关性。方法 选择2018年1月-2021年11月我院收治的226例IVD患者(LI组109例、TIA组117例),根据FAR平均值将两组患者分为LI低FAR组(≤0.11,n=61)、LI高FAR组(>0.11,n=48)及TIA低FAR组(≤0.11,n=68)、TIA高FAR组(>0.11,n=49);选择同期健康体检患者33例作为对照。分析5组患者治疗前FAR水平,采用多因素Logistic回归分析FAR水平与LI、TIA发生的相关性,采用ROC曲线评价FAR对LI与TIA的预测价值。结果 LI组:高FAR组中FAR较对照组及低FAR组FAR水平明显升高,差异有统计学意义(P<0.05);TIA组:高FAR组中FAR较对照组及低FAR组FAR水平明显升高,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,FAR是LI的独立危险因素。ROC曲线分析显示FAR是LI的良好预测因子。结论 FAR是LI的独立危险因素,对LI具有良好的预测价值,可作为LI的预测因子。

Objective The aim of this study was to analyze the relationship between serum fibrinogen to albumin ratio(FAR)and the main types of ischemic cerebrovascular disease(IVD):lacunar infarction(LI)and transient ischemic attack(TIA)before treatment.Methods Two hundreds and twenty-six IVD patients who were admitted to our hospital from January 2018 to November 2021 were collected,including 109 in Li group and 117 in TIA group.According to the average value of FAR,the two groups were divided into LILow FAR group(≤0.11,n=61),LI High FAR group(>0.11,n=48),TIA Low FAR group(≤0.11,n=68)and TIA High FAR group respectively(>0.11,n=49);Thirty-three healthy patients in the same period were selected as the control group.Pre-treatment FAR levels were analyzed in the five groups of patients,the FAR levels of the five groups were analyzed,the correlation between FAR levels and LI and TIA was analyzed by multivariate logistic regression,and the predictive value of FAR to LI and TIA was evaluated by ROC curve.Results Compared with the control group and Low FAR group,FAR in LI and TIA groups was increased(P≤0.05).Multivariate logistic regression analysis showed that FAR is an independent risk factor for LI,not for TIA.ROC curve analysis shows that the FAR can be a predictor of LI.Conclusion FAR is an independent risk factor for LI.It has good predictive value for LI,andit can be used as a predictor of LI.