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P2Y受体介导星形胶质细胞在中枢神经系统疾病中作用机制的研究进展

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摘要 星形胶质细胞是中枢神经系统(central nervous system,CNS)中数量最丰富的胶质细胞[1],除了在人体健康中发挥着免疫应答、滋养支持神经细胞、维持血脑屏障、促进髓鞘及突触形成以及保持内环境的稳态等重要神经系统保护作用外[2],有研究发现星形胶质细胞在一些条件下会释放炎症因子如白细胞介素-1α、肿瘤坏死因子、IL-6等加剧炎性反应,导致神经毒性作用损害机体功能,诱导疾病的发生发展[3].
出处 《中风与神经疾病杂志》 CAS 2023年第5期459-462,共4页 Journal of Apoplexy and Nervous Diseases
基金 国家自然科学基金项目(No.81860210) 内蒙古自然科学基金项目(No.2019BS08008)。
关键词 三磷酸腺苷 P2Y受体 星形胶质细胞 钙信号 中枢神经系统 Adenosine triphosphate P2Y receptor Astrocyte Calcium signal Central nervous system
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