聚类规则间隔短回文重复序列及其相关蛋白9系统用于单纯疱疹病毒治疗的研究进展

Research progress on clustered regularly interspaced short palindromic repeats-associated 9 system for the treatment of HSV

单纯疱疹病毒(HSV)是一种双链DNA包膜病毒, 主要通过感染机体的皮肤和神经组织致病, 对人体造成严重的危害。HSV因存在潜伏期与再激活作用状态, 因此如何对其进行快速检测及根治一直是临床治疗的难点。近年来, 聚类规则间隔短回文重复序列及其相关蛋白9系统由于其设计简单、靶向效率高, 因而在基因编辑和检测领域发展迅速。

Herpes simplex virus(HSV)is a double-stranded DNA enveloped virus that causes severe effects on the human body by infecting the skin and nerve tissues.Because of latency and reactivation,the rapid detection and eradication of HSV are great challenges for clinical treatments.In recent years,clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated 9(Cas9)system has developed rapidly in the field of gene editing and detection due to its simple design and high targeting efficiency.