靶向PD-L1的PET/CT分子探针研究进展

Research progress in PET/CT molecular probes targeting PD-L1

程序性死亡受体1(PD-1)/程序性死亡配体1(PD-L1)是肿瘤免疫治疗中重要的免疫检查点,PD-L1主要在肿瘤细胞和肿瘤相关髓样细胞中表达。放射性核素标记的靶向PD-L1分子探针可被PET/CT检测,使PD-L1表达在分子层面可视化,是指导免疫治疗的重要手段。靶向PD-L1的PET探针有抗体、多肽、小分子及其他类,目前部分探针应用于临床。笔者对靶向PD-L1的分子探针及临床应用进行综述。

Programmed cell death protein 1(PD-1)/programmed cell death ligand 1(PD-L1)is a pair of important immune checkpoint in tumor immunotherapy.PD-L1 expressed mainly in tumor cells and tumor-associated myeloid cells.The radionuclide-labeled molecular probe targeting PD-L1 can be detected by PET/CT and visualize PD-L1 expression at the molecular level,which is an important method to guide immunotherapy.PET probes targeting PD-L1 include antibodies,peptides,small molecules,and other probes,and some of them are currently used in clinical applications.This article reviews molecular probes targeting PD-L1 and their clinical applications.