阿尔茨海默病相关正电子显像剂的研究进展

Research progress in positron imaging agents for Alzheimer disease

阿尔茨海默病(AD)是老年人群中最常见的神经退行性疾病之一,其症状始于轻微的记忆困难,逐渐演变为认知功能障碍、复杂的日常活动功能障碍等。目前AD的早期诊断和鉴别诊断仍具有一定的挑战性,而β淀粉样蛋白(Aβ)和Tau蛋白等生物标志物在AD诊断中的作用越来越重要。笔者就AD诊断相关的正电子显像剂进行综述,以期让更多的医务工作者了解新的核医学显像技术,从而对AD进行早期诊断和治疗,延缓病情的恶化。

Alzheimer disease(AD)is one of the most common neurodegenerative diseases in the elderly.The symptoms of AD begin with mild memory difficulties and gradually evolve into cognitive dysfunction,complex daily activity disorders and so on.At present,the early and differential diagnosis of AD are still challenging,and biomarkers such as beta amyloid protein(Aβ)and Tau protein play a more and more important role in the diagnosis of AD.This paper reviews the positron imaging agents related to the diagnosis of AD,in order to let more medical workers understand the new nuclear medical imaging technology,so as to make early diagnosis and treatment of AD and delay the deterioration of the disease.