磁性分子印迹材料在生物大分子分离方面的研究及应用

Study and application of magnetic molecularly imprinted polymers in the separation of biomacromolecules

磁性分子印迹材料(MMIPs)具有识别性强、化学和物理稳定性高、生物兼容性好、回收简单、可重复使用等优点,已发展成为高亲和性、高选择性分离小分子物质的重要手段.生物大分子,如糖类、蛋白质和核酸等,因其传质阻力大、结构复杂,MMIPs在生物大分子分离方面的研究和应用相对滞后.本文简要介绍了MMIPs技术的原理、制备方法及其在生物医药、环境监测、环境治理等领域的应用现状,并重点综述了MMIPs分离生物大分子方面的最新进展和有待解决的问题,以期为MMIPs在生物大分子分离领域的发展和应用提供参考.

Magnetic molecularly imprinted polymers(MMIPs)have been developed as an important method to separate small molecules with high affinity and good selectivity due to their specific recognition,high physical-chemical stability,good biological compatibility,easy recovery and perfect reusability.However,the study and application of MMIPs in the separation of biological macromolecules is behind that of small molecular substances.As the biological macromolecules such as polysaccharides,proteins and nucleic acids,have the high mass transfer resistance and complex structure.In this paper,the principle,the preparation methods and applications of MMIPs are briefly introduced.Following,the latest developments and present problems in the field of biomacromolecule separation by MMIPs are critically reviewed.It is expected to provide references for the development and application of MMIPs in the separation of biological macromolecules.