卵巢癌组织中FAM83D的表达与临床病理特征及预后的相关性

Correlation of FAM83D Expression with Clinicopathological Characteristics and Prognosis in Ovarian Cancer

目的探讨FAM83D在卵巢癌组织中的表达及其临床意义。方法选取80例卵巢癌患者为研究对象,收集患者的癌组织与癌旁正常组织,以免疫组织化学法检测两种组织中FAM83D表达情况。同时,收集全部患者的年龄等一般资料,分析FAM83D表达与患者临床病理特征之间的关系。随访1年,以Kaplan-Meier法分析FAM83D表达与卵巢癌患者预后的关系。结果癌组织FAM83D阳性表达率85.00%(68/80)高于癌旁正常组织25.00%(20/80),有统计学差异(P<0.05)。FAM83D表达与卵巢癌患者的年龄、体重指数(BMI)、肿瘤病理分型无关,无统计学差异(P>0.05);FAM83D表达与肿瘤的临床分期、分化程度、淋巴结转移、直径有关,有统计学差异(P<0.05)。Kaplan-Meier结果显示:FAM83D阳性表达患者的1年生存率低于阴性表达患者,有统计学差异(P<0.05)。结论卵巢癌组织内FAM83D呈高表达,其表达水平与肿瘤临床分期、分化程度、淋巴结转移、直径等临床病理特征密切相关,FAM83D可能参与肿瘤的发生与发展,且阳性表达的患者生存率更低,预后更差。

Objective To investigate the expression of FAM83D in ovarian cancer and its clinical significance.Methods 80 patients with ovarian cancer were selected as the study subjects,and the expression of FAM83D in cancer tissues and adjacent normal tissues was detected by immunohistochemistry;At the same time,general data such as the age of all patients were collected to analyze the relationship between the expression of FAM83D and the clinicopathological characteristics of patients.During 1-year follow-up,the relationship between the expression of FAM83D and the prognosis of ovarian cancer patients was analyzed using Kaplan Meier method.Results The positive expression rate of FAM83D in cancer tissue was 85.00%(68/80)higher than that in normal tissue adjacent to cancer(25.00%(20/80)),with statistically significant difference(P<0.05).The expression of FAM83D was not significantly correlated with age,body mass index(BMI),and pathological classification of ovarian cancer patients(P>0.05);The expression of FAM83D was significantly correlated with clinical stage,degree of differentiation,lymph node metastasis,and tumor diameter(P<0.05).Kaplan Meier's results showed that the 1-year survival rate of patients with positive FAM83D expression was significantly lower than that of patients with negative FAM83D expression(P<0.05).Conclusion FAM83D is highly expressed in ovarian cancer tissue,and its expression level is closely related to clinical and pathological characteristics such as clinical stage,differentiation,lymph node metastasis,tumor diameter,etc.FAM83D may be involved in the occurrence and development of tumors,and patients with positive expression of FAM83D have a lower survival rate and worse prognosis.