白蛋白结合型紫杉醇联合三维适形放疗治疗局部晚期食管鳞癌的疗效及安全性

Efficacy and Safety of Albumin-bound Paclitaxel Combined with Three-dimensional Conformal Radiotherapy in Treating Locally Advanced Esophageal Squamous Cell Carcinoma

目的探讨白蛋白结合型紫杉醇联合三维适形放疗治疗局部晚期食管鳞癌的疗效及安全性。方法选取72例局部晚期食管鳞癌患者为研究对象,按数字表法分为对照组与观察组,各36例。对照组采用三维适形放疗治疗,观察组在对照组基础上联合白蛋白结合型紫杉醇治疗。2个月后,对比2组近期疗效、卡氏(KPS)评分、生化指标[血清环氧化酶-2(COX-2)、血管内皮生长因子C(VEGF-C)]及不良反应。结果①观察组完全缓解率为36.11%,高于对照组的13.89%(P<0.05);观察组总有效率为75.00%,高于对照组的50.00%(P<0.05)。②治疗前,2组KPS评分差异无统计学意义(P>0.05);治疗后,2组KPS评分均较治疗前升高(P<0.05),且观察组的KPS评分较对照组高(P<0.05)。③治疗前,2组血清COX-2、VEGF-C水平差异无统计学意义(P>0.05);治疗后,2组血清COX-2、VEGF-C水平均降低(P<0.05),且观察组的血清COX-2、VEGF-C水平均低于对照组(P<0.05)。④2组在治疗期间均未出现Ⅳ度不良反应,且2组不良反应发生情况比较无统计学差异(P>0.05)。结论白蛋白结合型紫杉醇联合三维适形放疗治疗局部晚期食管鳞癌可提高疗效,改善患者健康状况,降低血清COX-2和VEGF-C水平,且安全性值得肯定。

Objective To explore the efficacy and safety of albumin-bound paclitaxel combined with three-dimensional conformal radiotherapy in the treatment of locally advanced esophageal squamous cell carcinoma.Methods 72 patients with locally advanced esophageal squamous cell carcinoma were selected as the research subjects and divided into the control group and the observation group according to the number table method,with 36 cases in each group.The control group was treated with three-dimensional conformal radiotherapy while the observation group was combined with albumin-bound paclitaxel on the basis of the control group.After 2 months,the short-term efficacy,Karnofsky performance status(KPS)score,biochemical indicators[serum cyclooxygenase-2(COX-2),vascular endothelial growth factor C(VEGF-C)]and adverse reactions were compared between the 2 groups.Results①The complete remission rate in the observation group was 36.11%,which was higher than 13.89%in the control group(P<0.05).The total effective rate was 75.00% in the observation group,which was higher than 50.00% in the control group(P<0.05).②There was no statistical difference in KPS score between the 2 groups before treatment(P>0.05).After treatment,the KPS score of the 2 groups was increased compared with that before treatment(P<0.05),and the KPS score in the observation group was higher than that in the control group(P<0.05).③There were no statistically significant differences in the levels of serum COX-2 and VEGF-C between the 2 groups before treatment(P>0.05).The levels of serum COX-2 and VEGF-C in the 2 groups were decreased after treatment(P<0.05),and the above levels in the observation group were lower compared to the control group(P<0.05).④There were no gradeⅣadverse reactions in the 2 groups during treatment,and there were no statistical differences in the occurrence of adverse reactions between the 2 groups(P>0.05).Conclusion Albumin-bound paclitaxel combined with three-dimensional conformal radiotherapy can enhance the efficacy,improve the health status and reduce the levels of serum COX-2 and VEGF-C in the treatment of locally advanced esophageal squamous cell carcinoma,and its safety is worthy of recognition.