摘要
本文采用静电喷雾法实现了聚己二酸对苯二甲酸丁二醇酯(PBAT)可生物降解中空微球的可控制备,并且通过加入聚乙烯醇缩丁醛(PVB)对其结构进行调控。而后用于药物负载进行了缓释研究,通过20 d的体外降解实验发现,PBAT/PVB微球的降解速率比纯PBAT微球快4.35%。然后将它们成功地用于负载厄洛替尼(市售抗癌药),经过3周的体外释放实验,添加PVB的微球比纯PBAT微球累积释放厄洛替尼快14.24%。
Controllable preparation of polybutylene adipate terephthalate(PBAT)biodegradable hollow microspheres were achieved by electrostatic spray method and its structure was regulated by adding polyvinyl butyral(PVB).Through 20 d of in vitro degradation experiments,it is found that the degradation rate of PBAT/PVB microspheres is 4.35%faster than that of pure PBAT microspheres.Then they are successfully used to load erlotinib(a commercially available anticancer drug).After 3 weeks of in vitro release experiments,the cumulative release of erlotinib from PVB-added microspheres is 14.24%faster than that of pure PBAT microspheres.
作者
谢川
韦元智
李泽阳
刘玉飞
余佳
程莎
韦仕南
曾晞
骆衡
XIE Chuan;WEI Yuanzhi;LI Zeyang;LIU Yufei;YU Jia;CHENG Sha;WEI Shinan;ZENG Xi;LUO Heng(College of Chemistry and Chemical Engineering,Guizhou University,Guiyang 550025,China;Department of Polymer Materials and Engineering,College of Materials and Metallurgy,Guizhou University,Guiyang 550025,China;National Engineering Research Center for Composite Modified Polymer Materials,Guiyang 550014,China;Key Laboratory of Natural Products Chemistry,Chinese Academy of Sciences,Guiyang 550014,China;State Key Laboratory of Medicinal Plant Efficacy and Utilization,Guizhou Medical University,Guiyang 550014,China)
出处
《塑料工业》
CAS
CSCD
北大核心
2023年第5期69-74,85,共7页
China Plastics Industry
基金
贵州大学自然科学专项基金(贵大特岗合字(2021)44号)
贵州省“百”层次创新型人才培养项目(编号黔科合平台人才-GCC[2022]034-1)。
